Anticonvulsant hypersensitivity syndrome (AHS) is a rare, but severe and potentially fatal, adverse reaction that occurs in patients who are treated with commonly used older anticonvulsant drugs (phenytoin, carbamazepine and phenobarbital) and/or with some newer agents (lamotrigine). Ben m'rad M, Leclerc-Mercier S, Blanche P, et al. Department of Pharmacy Practice, Nesbitt College of Pharmacy and Nursing, Wilkes University, Wilkes‐Barre, PennsylvaniaDepartment of Pharmacy Practice, System Therapeutics, Geisinger Medical Center, Danville, PennsylvaniaDepartment of Pharmacy Practice, Nesbitt College of Pharmacy and Nursing, Wilkes University, Wilkes‐Barre, PennsylvaniaDepartment of Pharmacy Practice, Nesbitt College of Pharmacy and Nursing, Wilkes University, Wilkes‐Barre, PennsylvaniaDepartment of Pharmacy Practice, System Therapeutics, Geisinger Medical Center, Danville, PennsylvaniaDepartment of Pharmacy Practice, Nesbitt College of Pharmacy and Nursing, Wilkes University, Wilkes‐Barre, PennsylvaniaUse the link below to share a full-text version of this article with your friends and colleagues.

This syndrome has been associated with the use of aromatic ring‐containing agents such as phenytoin, carbamazepine, or phenobarbitone. Anticonvulsant hypersensitivity syndrome: Symptoms usually develop 2-6 weeks after starting the drug but may happen at any time; Symptoms include the triad of fever, generalised maculopapular rash, and lymphadenopathy; The rash spreads to varying degrees over the trunk and extremities; © 2020 American College of Clinical Pharmacy Descamps V, Bouscarat F, Laglenne S, et al. Although the anticonvulsant hypersensitivity syndrome was first described in 1950, confusion still abounds regarding the syndrome. eCollection 2016.Indian J Pharmacol. Epub 2012 Nov 20.J Pediatr Pharmacol Ther. Please enable it to take advantage of the complete set of features! It has been most commonly reported with the use of phenytoin, carbamazepine, and phenobarbital. This means that patients with a history of AHS should avoid further use of any aromatic anticonvulsant drug. doi: 10.1136/bcr.10.2008.1076. 2007 Oct;27(10):1425-39. doi: 10.1592/phco.27.10.1425.Indian J Med Sci. The anticonvulsant hypersensitivity syndrome (AHS) is an idiosyncratic immunologic reaction to certain anticonvulsant medications, in which internal organ involvement may lead to fatal multisystemic failure. Pharmacotherapy. Unable to load your collection due to an error Diagnosis is most frequently based on the recognition of this triad of symptoms and clinical judgment. COVID-19 is an emerging, rapidly evolving situation. Drug reaction with eosinophilia and systemic symptoms (DRESS), also termed drug-induced hypersensitivity syndrome (DIHS), is a rare reaction to certain medications.It involves primarily a widespread skin rash, fever, swollen lymph nodes, and characteristic blood abnormalities such as an abnormally high level of eosinophils, low number of platelets, and increased number of … The syndrome has been reported with aromatic antiepileptic drugs (AEDS); such as phenytoin, carbamazepine and phenobarbital [].AHS is a triad of fever, rash, and internal organ involvement. It is mainly caused by drugs such as phenytoin, phenobarbital, and carbamazepine. 2006 Feb;60(2):59-63. doi: 10.4103/0019-5359.19914.Expert Opin Drug Saf. Epub 2009 May 25. Unable to load your delegates due to an error It has been most commonly reported with the use of phenytoin, carbamazepine, and phenobarbital. Atypon 2013;6(1):100-4. Arene oxides, the toxic intermediaries in the metabolism of anticonvulsant drugs, can accumulate and directly bind to macromolecules, causing cell death, as well as act as prohaptens that bind to T cells, initiating an immune response and systemic reactions. The triad of fever, rash and internal organ involvement occurring 1 to 8 weeks after exposure to an anticonvulsant heralds this rare (1 in 1000 to 10 000 exposures) but serious reaction. Aromatic anticonvulsants [phenytoin, … and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username Drug-induced hypersensitivity syndrome: clinical and biologic disease patterns in 24 patients.

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