Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin. Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5% is not for use in your mouth, eyes or vaginaIt is important to spread the gel over your entire face. Mean systemic bioavailability of topical clindamycin in BenzaClin Topical Gel is suggested to be less than 1%.. Benzoyl peroxide has been shown to be absorbed by the skin where it is … If it does get into any of these areas, wash with water. Do not give Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5% to other people, even if they have the same condition you have. In a 2-year dermal carcinogenicity study in mice, treatment with the gel formulation at doses of 900, 2700, and 15000 mg/kg/day (1.8, 5.4, and 30 times the MRHD for clindamycin and 3.6, 10.8, and 60 times the MRHD for benzoyl peroxide, respectively, based on BSA comparisons) did not cause any increase in tumors. How should I store Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5%?Keep Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5% and all medicines out of the reach of children.
Benzoyl peroxide has been found to cause DNA strand breaks in a variety of mammalian cell types, to be mutagenic in Fertility studies have not been performed with Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5% or benzoyl peroxide, but fertility and mating ability have been studied with clindamycin. On Day 1, the mean (± standard deviation) peak plasma concentration (CBenzoyl peroxide has been shown to be absorbed by the skin where it is converted to benzoic acid.Clindamycin binds to the 50S ribosomal subunits of susceptible bacteria and prevents elongation of peptide chains by interfering with peptidyl transfer, thereby suppressing bacterial protein synthesis.Clindamycin and benzoyl peroxide individually have been shown to have Carcinogenicity, mutagenicity, and impairment of fertility testing of Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5% have not been performed.Benzoyl peroxide has been shown to be a tumor promoter and progression agent in a number of animal studies. Benzoyl peroxide and clindamycin topical (for the skin) is a combination medicine used to treat acne.

To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X.If you no longer wish to have this DailyMed RSS service, simply delete the copied URL from your RSS Reader. [Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5% is contraindicated in patients with a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis. It may harm them. Epub 2011 Jul 11.Clin Pharmacokinet. HOW SUPPLIED AND COMPOUNDING INSTRUCTIONS Prior to dispensing, tap the vial until powder flows freely. Epub 2011 Jul 1.Pannu J, McCarthy A, Martin A, Hamouda T, Ciotti S, Ma L, Sutcliffe J, Baker JR Jr.Antimicrob Agents Chemother. (1) Mean absolute change from baseline at Week 12 in:(2) Percent of subjects who had a 2-grade improvement from baseline on an Evaluator’s Global Severity (EGS) score.The EGS scoring scale used in all of the clinical trials for clindamycin phosphate and benzoyl peroxide gel, 1.2%/2.5% is as follows:Normal, clear skin with no evidence of acne vulgarisRare non-inflammatory lesions present, with rare non-inflamed papules (papules must be resolving and may be hyperpigmented, though not pink-red)Some non-inflammatory lesions are present, with few inflammatory lesions (papules/pustules only; no nodulocystic lesions)Non-inflammatory lesions predominate, with multiple inflammatory lesions evident: several to many comedones and papules/pustules, and there may or may not be one small nodulocystic lesionInflammatory lesions are more apparent, many comedones and papules/pustules, there may or may not be a few nodulocystic lesionsHighly inflammatory lesions predominate, variable number of comedones, many papules/pustules and many nodulocystic lesionsThe results of Trial 1 at Week 12 are presented in Table 2:The results of Trial 2 at Week 12 are presented in Table 3:Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5% is a white to off-white smooth gel supplied as:Advise the patient to read the FDA-approved patient labeling (Patient Information).Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5% is a prescription medicine used on the skin (topical) to treat acne vulgaris in people 12 years of age and older. Double-blind, randomized studies with larger numbers that specifically look at the treatment of acne in this increasingly important population are needed to provide additional insights into specific management challenges.”Please login or register first to view this content.Copyright © 2020 Haymarket Media, Inc. All Rights ReservedYou’ve viewed {{metering-count}} of {{metering-total}} articles this month.

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