Atrovent HFA (ipratropium bromide HFA) is an anticholinergic bronchodilator, packaged in an inhaler, used for maintenance and treatment of bronchospasm associated with chronic obstructive pulmonary disease (), including chronic bronchitis, and emphysema.Atrovent HFA is available as a generic termed ipratropium bromide.

Published by Elsevier Ltd. All rights reserved. Author information: (1)Department of Anaesthesia, Queen's University, Kingston, Ontario, Canada.

The pulse pressure would have been expected to increase, since salbutamol MDI and MDI-spacer were not significantly different, which does not confirm. In accordance with the findings of time domain analysis, increased HF/total power ratio seen with salbutamol inhalation but not with ipratropium supports the consideration that ipratropium attenuates the parasympathetic drive, which may counterbalance sympathetic stimulation during handgrip exercise. All records were visually examined and manually over-read to verify beat classification. STUDY OBJECTIVE: Systemic administration of beta-agonist and anticholinergic drugs markedly impair normal autonomic heart rate control.

In time domain analyses, ipratropium administration resulted in a reduced mean-RR, SDNN and RMSSD during handgrip exercise compared with baseline values (775 ± 30 ms vs. 748 ± 21 ms, Ipratropium inhalation may alter autonomic control of the heart rate in therapeutic doses during mild sympathetic stimulation in healthy subjects, while salbutamol does not show these effects.Thirteen healthy male volunteers, mean age 26 ± 2 years (range 23–28 years), were studied in a randomized, double-blind, placebo-controlled, crossover design study. Search for other works by this author on: Wiley Pras E, Stienlauf S, Pinkhas J, Sidi Y "Urinary retention associated with ipratropium bromide." Patterns of increasing beta-agonist use and the risk of fatal or near-fatal asthmaThe use of beta-agonists and the risk of death and near-death from asthmaIpratropium bromide: a review of its pharmacological properties and therapeutic efficacy in asthma and chronic bronchitisHemodynamic and non-bronchial effects of ipratropium bromideEffects of aerosol ipratropium bromide on cardiac vagal toneThe acute effects of inhaled salbutamol on the beat-to-beat variability of heart rate and blood pressure assessed by spectral analysisComparison of the acute effects of salbutamol and terbutalin on heart rate variability in adult asthmatic patientsSalbutamol inhalation has no effect on myocardial ischaemia, arrhythmias and heart rate variability in patients with coronary artery disease plus asthma or chronic obstructive pulmonary diseaseEffects of inhaled albuterol and ipratropium bromide on autonomic control of the cardiovascular systemA comparison of the bronchodilator activity of Sch 1000 and salbutamolPharmacokinetics and pharmacodynamics of cumulative single doses of inhaled salbutamol enantiomers in asthmatic subjectsHeart rate spectral analysis, cardiac norepinephrine spillover, and muscle sympathetic nerve activity during human sympathetic nervous activation and failureSpontaneous cardiac baroreflex activity in humans: comparison with pharmacological responsesAlpha-agonist modifies baroreflex vasoconstriction by a postjunctional mechanism in dogsSpectral analysis of heart rate variability in bronchial asthmaTime domain, geometrical and frequency domain analysis of cardiac vagal outflow: effects of various respiratory patternsComparison of baroreflex sensitivity and heart period variability after myocardial infarctionBaroreflex sensitivity, clinical correlates, and cardiovascular mortality among patients with first myocardial infarctionImpaired vagal heart rate control in coronary artery disease© 2004 The European Society of Cardiology. Postgrad Med J 65 (1989): 260-114. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information -

Drugs 20 (1980): 237-66. 1 thank.

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