If heart failure develops, it should be managed according to current standards of care, and discontinuation or dose reduction of the PPAR-gamma agonist must be considered.Malfunction of the insulin pump or insulin infusion set or insulin degradation can rapidly lead to hyperglycemia and ketoacidosis. These are commonly prescribed generic drugs. These antibodies do not appear to cause deterioration in glycemic control or necessitate an increase in insulin dose. You may give other people a serious infection or get a serious infection from them.If your dose is more than 60 units, you will need to give yourself more than 1 injection.Humalog KwikPen is available in 2 strengths, 100 units/mL and 200 units/mL. For more information on Humalog and insulin, go to www.Humalog.com.This Instructions for Use has been approved by the U.S. Food and Drug Administration.Copyright © 1996, 2019, Eli Lilly and Company. In Fischer 344 rats, a 12-month repeat-dose toxicity study was conducted with insulin lispro at subcutaneous doses of 20 and 200 units/kg/day (approximately 3 and 32 times the human subcutaneous dose of 1 unit/kg/day, based on units/body surface area). You may give other people a serious infection or get a serious infection from them.People who are blind or have vision problems should not use the Pen without help from a person trained to use the Pen.Always use a new needle for each injection to help prevent infections and blocked needles. Monitor potassium levels in patients at risk for hypokalemia if indicated (e.g., patients using potassium-lowering medications, patients taking medications sensitive to serum potassium concentrations).Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin. You may give other people a serious infection or get a serious infection from them.This Pen has been made to deliver the dose that is shown in the Dose Window. Effect of HUMALOG 7.3 Drugs That May Increase orDecrease the BloodGlucose Lowering Effect of HUMALOG 7.4 Drugs That May Blunt Signs and Symptoms of Hypoglycemia 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy 8.2 Lactation 8.4 Pediatric Use 8.5 Geriatric Use 8.6 Renal Impairment 8.7 Hepatic Impairment 10 OVERDOSAGE 11 DESCRIPTION 12 CLINICAL PHARMACOLOGY 12.1 … Bioavailability of Humalog is similar to that of regular human insulin. Problems include pump malfunction, infusion set occlusion, leakage, disconnection or kinking, and degraded insulin. This can cause severe breathing problems, irregular heartbeat, and death. Do not transfer insulin from your Pen to a syringe. This includes prescription and over-the-counter medicines, vitamins, and herbal products.Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Humalog only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2020 Cerner Multum, Inc. As with all insulin preparations, the glucose lowering effect time course of Humalog may vary in different individuals or at different times in the same individual and depends on many conditions, including the area of injection as well as the injection site blood supply and temperature Patients and caregivers must be educated to recognize and manage hypoglycemia. These are also generic drugs, but they cost a little more than drugs in Tier 1. Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems.Tell your doctor if you are pregnant or breastfeeding.Follow your doctor's instructions about using Humalog Use Humalog exactly as it was prescribed for you. You may give other people a serious infection or get a serious infection from them.If your dose is more than 60 units, you will need to give yourself more than 1 injection.People who are blind or have vision problems should not use the Pen without help from a person trained to use the Pen.Always use a new needle for each injection to help prevent infections and blocked needles. Insulin lispro did not produce important target organ toxicity including mammary tumors at any dose.Insulin lispro was not mutagenic in the following genetic toxicity assays: bacterial mutation, unscheduled DNA synthesis, mouse lymphoma, chromosomal aberration and micronucleus assays.Male fertility was not compromised when male rats given subcutaneous insulin lispro injections of 5 and 20 units/kg/day (0.8 and 3 times the human subcutaneous dose of 1 unit/kg/day, based on units/body surface area) for 6 months were mated with untreated female rats. SilverScript Medicare Part D formulary tiers indicate the level of cost-sharing for a covered drug. SilverScript plans use a system with five Medicare formulary tiers. Tier 2 includes the drug classes of thiazolidinediones and GLP-1 receptor agonists. Please check the formulary for different brand and generic drug names.

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