Naratriptan would appear to have lower recurrent headache rate than sumatriptan, rizatriptan or zolmitriptan. Name must be less than 100 characters 1991;32:581–4.Rolan P. Potential drug interactions with the novel antimigraine compound zolmitriptan (Zomig™, 311C90). 0000008474 00000 n

0000001542 00000 n Cephalalgia. All the new-marketed TELs have potential clinical benefits and were well-tolerated relative to sumatriptan. Br J Clin Pharmacol. Clipboard, Search History, and several other advanced features are temporarily unavailable. Cephalalgia. 0000004942 00000 n 0000005367 00000 n 2007;47:266–9.Joffe RT, Sokolov STH. Lack of pharmacokinetic interaction between the antimigraine compound, almotriptan, and propranolol in healthy volunteers.

Effect of prophylactic migraine medications on the pharmacokinetic and pharmacodynamic profiles of sumatriptan. The notable exception being eletriptan, where an active P-glycoprotein blood-brain barrier efflux system effectively negates these benefits and requires an 80 mg oral dose.

0000011221 00000 n 1997;14:221–5.Van Hecken AM, Depré M, de Schepper PJ, et al. All generic drug interactions for sumatriptan oral (lists will include brand and generic names): 8 contraindicated drug interactions 124 significant drug interactions 0000003347 00000 n Headache.

1996;11(5):300–4.Seaber EJ, Ridout G, Layton G, et al. The recent clinical development of a number of migraine specific 5-HT1B/1D agonist triptans with enhanced lipophilicity (TELs), relative to the first drug of this class sumatriptan, and with a range of different metabolic, pharmacokinetic and receptor affinity profiles, provides the potential for critically different clinical profiles. 0000010344 00000 n H�b```f``y����������X��, �J�:z���á@Sw���>�~��:��?j``q ���h`PU0��b�30�, ��@�e�e� s4�G���!Bٚ�k���3#� 6#^G���$�j��]�3ci�:��� This site needs JavaScript to work properly. Headache. 2000;40(3):309–15.Van Haarst AD, Van Gerven JMA, Cohen AF, et al. ���`� �) endstream endobj 62 0 obj 177 endobj 26 0 obj << /Type /Page /Parent 12 0 R /Resources 27 0 R /Contents [ 32 0 R 36 0 R 38 0 R 40 0 R 44 0 R 50 0 R 52 0 R 54 0 R ] /MediaBox [ 0 0 612 792 ] /CropBox [ 0 0 612 792 ] /Rotate 0 >> endobj 27 0 obj << /ProcSet [ /PDF /Text ] /Font << /F3 41 0 R /F4 33 0 R /F5 28 0 R /F6 47 0 R >> /ExtGState << /GS1 57 0 R >> >> endobj 28 0 obj << /Type /Font /Subtype /Type1 /FirstChar 30 /LastChar 181 /Widths [ 556 556 250 333 408 500 500 833 778 180 333 333 500 564 250 333 250 278 500 500 500 500 500 500 500 500 500 500 278 278 564 564 564 444 921 722 667 667 722 611 556 722 722 333 389 722 611 889 722 722 556 722 667 556 611 722 722 944 722 722 611 333 278 333 469 500 333 444 500 444 500 444 333 500 500 278 278 500 278 778 500 500 500 500 333 389 278 500 500 722 500 500 444 480 200 480 541 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 333 444 444 0 500 1000 0 0 0 0 0 0 0 0 250 0 500 500 0 0 0 0 0 760 0 0 0 333 0 0 0 564 0 0 0 500 ] /Encoding 29 0 R /BaseFont /KLMDFM+Times-Roman /FontDescriptor 30 0 R >> endobj 29 0 obj << /Type /Encoding /BaseEncoding /WinAnsiEncoding /Differences [ 17 /Zcaron /zcaron /Lslash /lslash /minus /fraction /breve /caron /dotlessi /dotaccent /hungarumlaut /ogonek /ring /fi /fl ] >> endobj 30 0 obj << /Type /FontDescriptor /Ascent 699 /CapHeight 662 /Descent -217 /Flags 34 /FontBBox [ -168 -218 1000 898 ] /FontName /KLMDFM+Times-Roman /ItalicAngle 0 /StemV 84 /XHeight 450 /CharSet (/seven/D/comma/l/t/eight/e/G/hyphen/u/quotedblright/Y/f/fi/I/H/nine/peri\ od/v/colon/h/P/Z/fl/F/w/slash/J/semicolon/endash/i/L/d/y/N/zero/bracketl\ eft/j/M/z/n/one/A/k/O/bracketright/two/m/quoteright/x/three/K/parenleft/\ R/o/p/four/S/E/parenright/at/T/quotedblleft/five/q/U/g/B/emdash/r/six/V/\ b/C/s/a/W/c) /FontFile3 60 0 R >> endobj 31 0 obj 648 endobj 32 0 obj << /Filter /FlateDecode /Length 31 0 R >> stream

2001;41:217–23.Kempsford RD, Lacey LF, Thomas M, et al. The association of the combination of sumatriptan and methysergide in myocardial infarction in a premenopausal woman. Of more concern than pharmacokinetic interactions are pharmacodynamic interactions. The triptans are a group of compounds with high efficacy for the acute treatment of migraine and cluster headache. Explore Apps Drug Interactions with Triptans. the triptans are metabolized by phase I monoamine oxidases (MAOs) and by various cytochrome P450 enzymes.

COVID-19 is an emerging, rapidly evolving situation. They have a relatively wide therapeutic index, and although a number of minor pharmacokinetic interactions have been observed, few are likely to be clinically significant. 2005;352:1112–20.Tepper S, Allen C, Sanders D, et al. 0000021134 00000 n 0000002801 00000 n Clin Drug Investig. Br J Clin Pharmacol.

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