One form of the condition, known as …

Systemic sclerosis (systemic scleroderma) is a chronic condition that occurs in two forms:.

the problem is with your immune system, which causes your body to make too much of the protein collagen, an important part of your skin. A single copy of these materials may be reprinted for noncommercial personal use only.

We do not endorse non-Cleveland Clinic products or services. Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure. Scleroderma (sklair-oh-DUR-muh) is a group of rare diseases that involve the hardening and tightening of the skin and connective tissues.Scleroderma affects women more often than men and most commonly occurs between the ages of 30 and 50.

Most likely, scleroderma is caused by a combination of factors, including immune system problems, genetics and environmental triggers.Anyone can get scleroderma, but it does occur much more often in women than in men.

Signs and symptoms vary, depending on which type of scleroderma you have. In some people, scleroderma affects only the skin. In its most serious form (called scleroderma renal crisis), a rapid increase in blood pressure may occur, resulting in kidney failure.
We do not endorse non-Cleveland Clinic products or services. scleroderma is a chronic skin disease. But in … © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Scleroderma's signs and symptoms vary, depending on which parts of your body are affected:Scleroderma results from an overproduction and accumulation of collagen in body tissues. Because scleroderma can take so many forms and affect so many different areas of the body, it can be difficult to diagnose.After a thorough physical exam, your doctor may suggest blood tests to check for elevated levels of certain antibodies produced by the immune system. Although it most often affects the skin, scleroderma also can affect many other parts of the body. Scleroderma (sklair-oh-DUR-muh) is a group of rare diseases that involve the hardening and tightening of the skin and connective tissues.Scleroderma affects women more often than men and most commonly occurs between the ages of 30 and 50. Diffuse cutaneous systemic sclerosis—the diffuse subset is seen in 10% of systemic scleroderma, often progressing quickly, and is potentially fatal.It can affect large areas of skin, causing thickening and hardening of the skin (sclerosis), abnormal changes with the arteries, joint … Kidney function can be assessed through blood tests. Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. Scleroderma is a chronic but rare autoimmune disease in which normal tissue is replaced with thick tissue with extra collagen. Advertising on our site helps support our mission. While there is no cure for scleroderma, a variety of treatments can ease symptoms and improve quality of life.There are many different types of scleroderma. Because it can affect other parts of the body — such as the joints — scleroderma may be initially mistaken for After discussing your personal family medical history, your doctor will perform a thorough Last reviewed by a Cleveland Clinic medical professional on 09/16/2019. 9500 Euclid Avenue, Cleveland, Ohio 44195 | The diagnosis of scleroderma is not always easy. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.

Kidney function: When scleroderma affects the kidneys, the result can be an increase in blood pressure as well as the leakage of protein into the urine. In some people, scleroderma affects only the skin. Cleveland Clinic is a non-profit academic medical center. Collagen is a fibrous type of protein that makes up your body's connective tissues, including your skin.Doctors don't know exactly what causes the abnormal collagen production to begin, but the body's immune system appears to play a role.
All rights reserved. Cleveland Clinic is a non-profit academic medical center. The disease can be either localized to the skin or involve other organs as well. He or she may also remove a small sample of your affected skin so that it can be examined in the laboratory.Your doctor may also suggest other blood tests and imaging or organ-function tests t… While there is no cure for scleroderma, a variety of treatments can ease symptoms and improve quality of life.There are many different types of scleroderma. But in many people, scleroderma also harms structures beyond the skin, such as blood vessels, internal organs and the digestive tract (systemic scleroderma). Get useful, helpful and relevant health + wellness informationCleveland Clinic offers expert diagnosis, treatment and rehabilitation for bone, joint or connective tissue disorders and rheumatic and immunologic diseases.

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