Evaluation of patients with hypertension or myocardial infarction should always include assessment of renal function.The frequency estimates in the following table were derived from controlled studies in hypertensive patients in which adverse reactions were either volunteered by the patient (US studies) or elicited, eg, by checklist (foreign studies). The reduction in atenolol clearance follows the general trend that the elimination of renally excreted drugs is decreased with increasing age.Tenormin is indicated for the treatment of hypertension, to lower blood pressure.
This effect is maximal at about 2 to 4 hours, and persists for at least 24 hours. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including atenolol.Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake.

Severe exacerbation of angina and the occurrence of myocardial infarction and ventricular arrhythmias have been reported in angina patients following the abrupt discontinuation of therapy with beta blockers. Hemodialysis 50 mg after each dialysis. Monitor blood pressure continuously.Based on the severity of symptoms, management may require intensive support care and facilities for applying cardiac and respiratory support.The initial dose of Tenormin is 50 mg given as one tablet a day either alone or added to diuretic therapy. Injection should be administered under carefully controlled conditions including monitoring of blood pressure, heart rate, and electrocardiogram. %PDF-1.7 %���� Atenolol is used with or without other medications to treat high blood pressure (hypertension).Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

Declines from peak levels are rapid (5- to 10-fold) during the first 7 hours; thereafter, plasma levels decay with a half-life similar to that of orally administered drug.
Beta Blocker Heart Meds Might Pose Special Risks for Women Concomitant use can increase the risk of bradycardia.Two long-term (maximum dosing duration of 18 or 24 months) rat studies and one long-term (maximum dosing duration of 18 months) mouse study, each employing dose levels as high as 300 mg/kg/day or 150 times the maximum recommended human antihypertensive doseFertility of male or female rats (evaluated at dose levels as high as 200 mg/kg/day or 100 times the maximum recommended human doseChronic studies employing oral atenolol performed in animals have revealed the occurrence of vacuolation of epithelial cells of Brunner's glands in the duodenum of both male and female dogs at all tested dose levels of atenolol (starting at 15 mg/kg/day or 7.5 times the maximum recommended human antihypertensive doseAtenolol is excreted in human breast milk at a ratio of 1.5 to 6.8 when compared to the concentration in plasma.

Caution should be exercised when Tenormin is administered during pregnancy or to a woman who is breast-feeding (See Safety and effectiveness in pediatric patients have not been established.Clinical studies of Tenormin did not include sufficient number of patients aged 65 and over to determine whether they respond differently from younger subjects. Peak blood levels are reached between two (2) and four (4) hours after ingestion. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

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