The pattern of adverse events seen in these patients is consistent across all age groups.

Method of administration: Foscarnet should be administered by the intravenous route only, either by a central venous line or in a peripheral vein. No evidence of oncogenicity was reported at plasma drug levels equal to 1/3 and 1/5, respectively, of those in humans (at the maximum recommended human daily dose) as measured by the area-under-the-time/concentration curve (AUC).Foscarnet sodium showed genotoxic effects in the BALB/3T3 Daily subcutaneous doses up to 75 mg/kg administered to female rats prior to and during mating, during gestation, and 21 days post-partum caused a slight increase (< 5%) in the number of skeletal anomalies compared with the control group.

SIDE EFFECTS: See also Warning section.Because this medication is used in patients who use other medications, it is difficult to tell which side effects are caused by foscarnet.Nausea, vomiting, headache, diarrhea, dizziness, loss of appetite, and increased sweating have been reported. Foscarnet may also be used for other serious viral infections as determined by your doctor. Consult your Sorry.

If you experience any of the following symptoms, call your doctor immediately: seizures; numbness or tingling around the mouth or in fingers or toes; fast, pounding, or irregular heartbeat; or muscle spasms.Keep all appointments with your doctor, including your eye doctor, and the laboratory. https://www.webmd.com/drugs/2/drug-11596/foscarnet-intravenous/details

All Foscarnet resistant isolates are known to be generated through amino acid substitutions in the viral DNA polymerase pUL54 (CMV) or pUL30 (HSV) (Y577H, E597D, A605V, L702H, V714M, L774F, L788M, D780N, L782I, P797T, L802F, V813M, V817M, Y818C, T821M, R842S, S889A, F891C, V892M, D907V, A910V, SRA914-916LCV, V958L, R959HN495K, Q578H/L, D588E/N, T700A, V715M, E756D/K/Q, L773V, L776M, V781I, V787L, L802M, A809V, V812L, T813S, T821I, A834P, T838A, G841A/S, del 981-982S599L, D672N, R700G V715G, A719T/V, S724N, E798K, G841C/S, A910T, Y941HA724T, S725G, S729N, Q732R, L783M, D785N, T844I, L850I, D912VThe possibility of viral resistance should be considered in patients who show poor clinical response or experience persistent viral excretion during therapy.Cross-Resistance: The amino acid substitutions that resulted in reduced susceptibility to Foscarnet and either ganciclovir, acyclovir and/or cidofovir are summarized in Q578H, D588N, E756K, L773V, L776M, V781I, V787L, L802M, A809V, V812L, T813S, T821I, A834P, G841A/S, del 981-982Q578H, D588N,E756K, L773V, V812L, T813S, A834P, G841A, del 981-982E597D, S599L, A605V, D672N, R700G, L702H, V714M, V715G, A719T/V, S724N, L774F, L778M, D780N, L782I, P797T, E798K, L802F, V813M, V817M, Y818C, T821M, G841C/S, R842S, S889A, F891C/Y, V892M, D907V, A910V/T, SRA914-916LCV, Y941H, V958L, V959HA724T, S725G, S729N, Q732R, L783M, D785N, T844I, D912VV714M, A719V, S724N, L778M, L802F, Y818C, T821M, G841SThe pharmacokinetics of Foscarnet has been determined after administration as an intermittent intravenous infusion during induction therapy in AIDS patients with CMV retinitis.

You may also be given IV fluids to keep you from getting dehydrated. The patient should be observed for signs and symptoms of renal impairment and electrolyte imbalance.

Case reports have documented both successful and disappointing results of foscarnet treatment for HHV-6 encephalitis in transplant recipients [3, 5, 8]. 4.2. You may need to mix foscarnet with a liquid (diluent) before using it.

If accidental contact occurs, the exposed area should be rinsed immediately with cold water. It is usually infused slowly over 1 to 2 hours every 8 or 12 hours.


ALL DOSES MUST BE INDIVIDUALIZED FOR PATIENTS’ RENAL FUNCTION.Because of physical incompatibility, Foscarnet sodium and ganciclovir must NOT be mixed.We comply with the HONcode standard for trustworthy health information - Each milliliter of Foscarnet sodium injection contains 24 mg of Foscarnet sodium hexahydrate in Water for Injection, USP.

Each milliliter of FOSCAVIR contains 24 mg of foscarnet sodium hexahydrate in Water for Injection, USP.
Foscarnet can precipitate in the presence of calcium, magnesium, and phosphorus, and these agents should not be given concurrently. Due to censoring on death, the latter analysis may overestimate the treatment effect. Foscarnet sodium injection contains no preservatives.Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. Do not store in the bathroom. It is also important information to carry with you in case of emergencies.URL of this page: https://medlineplus.gov/druginfo/meds/a601144.htmlTo use the sharing features on this page, please enable JavaScript.

The standard 24 mg/mL solution may be used with or without dilution when using a central venous catheter for infusion. Do not self-inject foscarnet if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

In patients with fluid overload, less (but not none) hydration may be given, recognizing the associated increased risk of nephrotoxicity. Patients received induction treatment of Foscarnet sodium, 60 mg/kg every 8 hours for 3 weeks, followed by maintenance treatment with 90 mg/kg/day until retinitis progression (appearance of a new lesion or advancement of the border of a posterior lesion greater than 750 microns in diameter).

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