Many of these side effects can be managed, and some may go away on their own over time. Methylphenidate: May diminish the antihypertensive effect of Antihypertensive Agents.Molsidomine: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Multivitamins/Fluoride (with ADE): May enhance the hypercalcemic effect of Thiazide and Thiazide-Like Diuretics.Multivitamins/Minerals (with ADEK, Folate, Iron): Thiazide and Thiazide-Like Diuretics may enhance the hypercalcemic effect of Multivitamins/Minerals (with ADEK, Folate, Iron). Aliskiren may enhance the nephrotoxic effect of Angiotensin II Receptor Blockers. Available for Android and iOS devices. These trials included 3149 patients randomized to fixed doses of irbesartan (37.5 to 300 mg) and concomitant hydrochlorothiazide (6.25 to 25 mg).Irbesartan and Hydrochlorothiazide Tablets USP are supplied as follows:Irbesartan and Hydrochlorothiazide Tablets USP 150 mg/12.5 mg:Irbesartan and Hydrochlorothiazide Tablets USP 300 mg/12.5 mg:Irbesartan and Hydrochlorothiazide Tablets USP 300 mg/25 mg:Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].Tell patients using Irbesartan and Hydrochlorothiazide Tablets that getting dehydrated can lower their blood pressure too much and lead to lightheadedness and possible fainting. Increases in serum lithium concentrations and lithium toxicity have been reported with concomitant use of irbesartan or thiazide diuretics. The largest incremental effect will likely be in the transition from monotherapy to 150 mg/12.5 mg Irbesartan and Hydrochlorothiazide Tablets may be substituted for the titrated components.The usual starting dose is Irbesartan and Hydrochlorothiazide Tablets 150 mg/12.5 mg once daily. Nonsteroidal Anti-Inflammatory Agents may diminish the therapeutic effect of Thiazide and Thiazide-Like Diuretics. Low Amount Of Potassium In The Blood 4. The combination of these two agents may also significantly decrease glomerular filtration and renal function. If combined, mecamylamine prescribing information suggests reducing the mecamylamine dose by 50% in order to avoid excessive hypotension.Methenamine: Thiazide and Thiazide-Like Diuretics may diminish the therapeutic effect of Methenamine. Available for Android and iOS devices. What are some other side effects of Irbesartan and Hydrochlorothiazide?

This risk may be increased with doses ≥25 mg (Gurwitz 1997).• Hypersensitivity reactions: Hypersensitivity reactions may occur with hydrochlorothiazide.

This product contains two medications: irbesartan and hydrochlorothiazide. Specifically, the risk for dehydration or hypokalemia may be increased.Diazoxide: Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of Diazoxide.

Management: Consider avoiding the use of mecamylamine and thiazide diuretics. This drug is available as the brand-name drug Hyzaar and as a generic drug. [see Clinical Pharmacology (12.3) and Clinical Studies (14)].We comply with the HONcode standard for trustworthy health information - Aliskiren may enhance the hypotensive effect of Angiotensin II Receptor Blockers. The primary treatment is to discontinue drug intake as rapidly as possible. Adults When blood pressure is not controlled with irbesartan, the initial dosage is 1 tablet Avalide 150—12.5 mg (irbesartan and HCTZ) PO once daily.

Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Porfimer: Photosensitizing Agents may enhance the photosensitizing effect of Porfimer. Indigestion 5.

Adjust dosage … Use cautiously, if at all, with these agents and monitor potassium closely. No dosage adjustment of Irbesartan/ Hydrochlorothiazide is necessary in patients with mild to moderate hepatic impairment (see section 4.3). We comply with the HONcode standard for trustworthy health information - Untreated acute angle-closure glaucoma can lead to permanent vision loss. Diazoxide: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Dichlorphenamide: Thiazide and Thiazide-Like Diuretics may enhance the hypokalemic effect of Dichlorphenamide.

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