Theophylline is a Pregnancy Category C drug, meaning that the drug has not been proven to cause fetal harm but no well-designed human trials are available. In 2017, Mohammed, et al.InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)Schack, Jerome A., and Samuel H. Waxler. Theophylline is sometimes used to support the treatment of asthma or COPD if you are not adherent to your daily inhaled steroid treatment. Theophylline is sometimes used to support the treatment of asthma or COPD if you are not adherent to your daily inhaled steroid treatment. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Studies have shown that doxofylline has similar efficacy to theophylline but with fewer side effects. However, if the missed dose is near the time of your next scheduled dose, simply skip the missed dose and continue as normal. However, doing so may cause side effects if the drug accumulates beyond a certain blood concentration. samples. Ⓒ 2020 About, Inc. (Dotdash) — All rights reservedAsthma Medication Side Effects You Should Know AboutWhat You Need to Know About Systemic CorticosteroidsAntihistamines May Help Your Asthma If It Is Caused by AllergiesIs Symbicort the Right Drug to Control Your Asthma?How Budesonide Is Use to Treat Asthma, IBD, and Allergic RhinitisHow Qvar Redihaler Compares to Other Inhaled SteroidsFasenra for Treatment of Severe Eosinophilic AsthmaWhat Are the Differences Between Inhaled and Oral Corticosteroids? Theophylline works by relaxing the smooth muscles of the airways while relieving inflammation and acting upon the respiratory center of the brain.

Oral theophylline can be taken with or without food. Clearance of the drug is increased in children (age 1 to 12), teenagers (12 to 16), adult smokers, elderly smokers, as well as in Theophylline was first extracted from tea leaves and chemically identified around 1888 by the German biologist Theophylline, despite its adverse effects and narrow therapeutic range, as discussed above, is still a potent bronchodilator. Glucocorticoids are a type of corticosteroid hormone that is very effective at reducing inflammation and suppressing the immune system. The remaining proton signal, at 8.01δ, corresponds to the proton on the imidazole ring, not transferred between the nitrogen. It can also be given intravenously (into a vein) for treatment for severe Journal of pharmacology and experimental therapeutics 97.3 (1949): 283-291.Shelke, R. U.; Degani, M. S.; Raju, A.; Ray, M. K.; Rajan, M. G. R. Fragment Discovery for the Design of Nitrogen Heterocycles as Mycobacterium tuberculosis Dihydrofolate Reductase Inhibitors. To avoid drug interactions, let your doctor known about any medications you may be taking whether they are prescription, over-the-counter, herbal, nutritional, or recreational. Not everyone will experience them, and some may only have side effects during the first week of treatment. Read our Barnes, P. J. Theophylline in Chronic Obstructive Pulmonary Disease: New Horizons. Theophylline belongs to a unique class of drugs called To ensure the appropriate drug concentrations are being maintained—ideally between 5 and 10 mcg/mL— Approximately 10% is excreted unchanged. Question 3 A 72-year-old man is prescribed theophylline for symptomatic relief of bronchial asthma. Sections. Women who are pregnant or intend to get pregnant should fully weigh the benefits and risks of treatment with their doctors. Z Lebensm Unters Forsch. Materials and Methods Patients. Doctors who prescribe it most commonly do so for the following purposes: The remaining signals correspond to carbons characteristic of the xanthine backbone.Trace amounts of theophylline are also found in brewed Trace amounts of theophylline are also found in guarana (It has been shown that theophylline may reverse the clinical observations of steroid insensitivity in patients with COPD and asthmatics who are active smokers (a condition resulting in Theophylline is distributed in the extracellular fluid, in the placenta, in the mother's milk and in the central nervous system. Some medications are known to interact with theophylline, including: The recommended dosage varies by age as well as the intended use. But rather than simply taking another drug to overcome an adherence problem, speak with your doctor about ways to improve your adherence, including daily cell phone reminders or psychotherapy if you have anxiety or depression (both of which can influence adherence). Theophylline is considered a component of a treatment plan. Mohamed, A. R.; Georgey, H. H.; George, R. F.; El-Eraky, W. I.; Saleh, D. O.; Abdel Gawad, N. M. Identification of some novel xanthine-based derivatives with bronchodilator activity. Corticosteroid insensitivity and reduced histone deacetylase-2 activity after oxidative stress were reversed by a non-selective PI3K inhibitor (LY294002) and low concentrations of theophylline.

Never double up theophylline doses either to "catch up" following a missed dose or to "load up" if you plan to be out and don't want to carry your medication along with you. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.

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