We comply with the HONcode standard for trustworthy health information - The estimated rate of suicidal behavior or ideation among 27,863 AED-treated patients was 0.43%, compared to 0.24% for 16,029 placebo-treated patients, representing an increase of approximately one case for every 530 patients treated. If patients have symptoms of suicidal ideation or behavior, treatment should be discontinued.Moderate Potential Hazard, Moderate plausibility. Select one or more newsletters to continue. Commonly reported side effects of lamotrigine include: ataxia, skin rash, headache, insomnia, and nausea.
Some of the patients who developed aseptic meningitis had underlying diagnoses of systemic lupus erythematosus and other autoimmune diseases.Moderate Potential Hazard, Moderate plausibility. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Applies to: Depression, PsychosisAntiepileptic drugs (AEDs) have been associated with an increased risk of suicidal thoughts or behavior in patients taking these drugs for any indication.
This occurred generally, but not solely in patients with underlying EKG abnormalities or risk factors for conduction abnormalities. Talk to your healthcare provider before taking the drug if you have liver, kidney, or heart problems. Therapy with AEDs should be administered cautiously in patients with depression or other psychiatric disorders. Inflammation Of The Nose 13. The risk did not vary substantially by age (5 to 100 years) in the clinical trials analyzed. The plasma clearance of lamotrigine may be decreased and the half-life prolonged in patients with impaired renal and/or hepatic function.
Chest Pain 4. All rights reserved. Applies to: Bone Marrow Depression/Low Blood CountsReports of blood dyscrasias that may or may not be associated with multi-organ hypersensitivity (also known as DRESS) have been reported in patients treated with lamotrigine. 1. Caregivers and family should be alert for the emergence or worsening of symptoms. Blurred Vision 3.
Rash If experienced, these tend to have a Less Severe expression 1. Throwing Up 18. However, clinical data are limited. by the degree of renal impairment. Applies to: Liver Disease, Renal DysfunctionLamotrigine is primarily converted by the liver to inactive glucuronide metabolites and subsequently eliminated by the kidney. The plasma clearance of lamotrigine may be decreased and the half-life prolonged in patients with impaired renal and/or hepatic function. For clinically significant or persistent symptoms, a dosage reduction or treatment withdrawal should be considered.
Join our mailing list to stay to date about programs, events, and news about epilepsy. The increased risk of suicidal thoughts or behavior was observed as early as one week after starting AEDs and persisted for the duration of treatment assessed. Applies to: Dermatitis - Drug-InducedSevere, potentially fatal reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis have been associated with the use of lamotrigine. Renal clearance of lamotrigine is Pooled analyses of 199 placebo-controlled clinical studies involving the use of 11 different AEDs across multiple indications in either monotherapy or adjunctive therapy for a median treatment duration of 12 weeks (up to a maximum of 24 weeks) showed that patients receiving AEDs had approximately twice the risk of suicidal thinking or behavior compared to patients receiving placebo. There were four suicides in AED-treated patients and none in placebo-treated patients, although the number is too small to establish any causal relationship. Only about 10% of lamotrigine is cleared by the kidney. There have been suggestions that the risk of rash may be increased by 1) coadministration with valproic acid, 2) exceeding the recommended initial dosage, or 3) exceeding the recommended rate of dosage escalation of lamotrigine.Moderate Potential Hazard, Moderate plausibility.
The elimination half-life of lamotrigine was approximately 25 h in subjects with normal renal function and 50 h in uraemic patients. Individual agents have demonstrated AV heart block, including second and third-degree block following treatment. If experienced, these tend to have a Severe expression 1. Therapy with these agents should be considered and administered cautiously in patients with a history of cardiovascular disease and conduction abnormalities.Moderate Potential Hazard, Moderate plausibility. In a study of 6 subjects on hemodialysis, an average of 20% (range 5.6% to 35.1%) of lamotrigine present in the body was eliminated during a 4-hour hemodialysis session.The mission of the Epilepsy Foundation is to lead the fight to overcome the challenges of living with epilepsy and to accelerate therapies to stop seizures, find cures, and save lives.8301 Professional Place West, Suite 230, Landover, MD 20785 | 1.800.332.1000Copyright © 2020.
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