Applies to promethazine: oral syrup, oral tabletOther dosage forms: 1. rectal suppository 2. solutionAlong with its needed effects, promethazine (the active ingredient contained in Phenergan) may cause some unwanted effects. Often, it’s caused by an adverse reaction to medication like anticonvulsants or antibiotics.. 1999; 56: 1742-1742.The Journal of Urgent Care Medicine® (JUCM) is the official journal of the Urgent Care Association (UCA). Medication Errors. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information - Cerner Multum, Inc. "UK Summary of Product Characteristics." 2009.
O 03. Infections of the skin and soft tissues range from mild superficial processes that can be managed in outpatients to life-threatening infections requiring hospitalization, intensive care, and combined surgical and medical support. The culture grew methicillin-resistant staphylococcus aureus (MRSA), for which IV vancomycin was added in addition to piperacillin-tazobactam. Promethazine hydrochloride should not be used in pediatric patients less than 2 years old because of the potential for fatal Along with its needed effects, promethazine (the active ingredient contained in Stop taking promethazine and get emergency help immediately if any of the following effects occur:Some side effects of promethazine may occur that usually Check with your health care professional if any of the following side effects The most commonly reported side effect include drowsiness, dizziness, and restlessness.1. Neurology. He had fasciotomy and wound vac placement. Skin necrosis, neurological damage, and loss of limb can follow. O 02. Toxic epidermal necrolysis (TEN) is a rare and serious skin condition. promethazine. This report reviews how to manage the complications of such adulterated heroin. Prompt recognition and vascular surgical consultation is imperative.
Physicians may not be fully aware that it is also toxic to the intima of blood vessels and surrounding connective tissue; this can result in severe tissue damage and necrosis.Although this is not a common side effect of this medicine, the purpose of this article is to bring awareness to and familiarize urgent care physicians with serious complications which can happen with this commonly used medication.Relief of pruritus due to various dermatologic conditionsThe patient underwent incision and drainage (I&D) of the abscess and received 25 mg of promethazine by intramuscular route on the right gluteal area.Immediately after, he reported a severe burning sensation going down his right thigh. The surgical team was consulted for possible fasciotomy of the right thigh.The patient was admitted for the treatment of cellulites and possible fasciotomy of the right thigh. He complained that the pain at the injection site was worse – so much so that he was unable to walk.CT scan of the right thigh demonstrated multiple congruent abscesses extending from the injection site on the right hip to the knee. Cerner Multum, Inc. "Australian Product Information." MacPherson RD, Rasiah RL, McLeod LJ. Extravasation of i.v. Due to the risks of intravenous injection, the preferred route of administration of Phenergan Injection is deep intramuscular injection.
In 2005, a patient received 12.5 mg of promethazine IV into an IV site in the hand. This powder is a toxic substance used to color the petals of plants.
Promethazine Hydrochloride (promethazine)." 2009; 73: e94-e95. the drug is also a known vesicant which is highly caustic to the intima of blood vessels and surrounding tissue.
Grissinger M. Preventing serious tissue injury with intravenous promethazine (Phenergan). He was started on intravenous fluids, the broad-spectrum antibiotic piperacillin-tazobactam (Zosyn), and the pain medication hydromorphone (Dilaudid).
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported. He remained in the hospital for one month and was later transferred to a rehabilitation facility.Administering promethazine by intravenous or intraarterial routes has been found to result in arterial spasm and, in turn, to impaired circulation and gangrene in specific cases.In 1999, Malesker, et al reported a similar experience with a 43-year-old woman who was admitted for a hysterectomy and received post-operative promethazine 25 mg every two hours by intravenous route for nausea and vomiting.More recently (2009), Grissinger described a case of a 19-year-old woman who received promethazine by intravenous route and developed pain and swelling at the site of injection in her right arm.Our case report clearly demonstrates the potential for serious complications associated with promethazine.Local anesthetic agents to promote vasodilatation, anticoagulation therapy, sympatholytic therapy (i.e., Stellate ganglion block), and limb elevation have all been described in case studies, with varying results.We, along with the manufacturer’s recommendations, suggest that the following strategies be considered to prevent or minimize tissue damage:Malesker MA, Malone PM, Cingle, et al.
Phenergan (promethazine)." problem: promethazine (phenergan) injection is a commonly used product that possesses antihistamine, sedative, anti-motion sickness, and antiemetic effects. Wyeth-Ayerst Laboratories, Philadelphia, PA. 4. Despite all therapy available, a good outcome is difficult to achieve. "Product Information. Necrotic Tissue is a condition where living skin necrosis means living skin dies as a result of blood and oxygen deprivation its cells. Soft-tissue necrosis as a result of intravenous leakage of phenytoin.
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