Levothyroxine systemic 50 mcg (0.05 mg) (M L 5) Philadelphia: Lippincott Williams & Wilkins; 2001:445-54.146. 112. Levothyroxine is a thyroid medicine that replaces a hormone normally produced by your thyroid gland to regulate the body's energy and metabolism.. Levothyroxine is used to treat hypothyroidism (low thyroid hormone).This medicine is given when your thyroid does not produce enough of this hormone on its own.

115. Ramos-Gabatin A, Jacobson JM, Young RL. Spigelman MK. WARNING: NOT FOR TREATMENT OF OBESITY OR FOR WEIGHT LOSSThyroid hormones, including Levothyroxine Sodium Injection, should not be used for the treatment of obesity or for weight loss.Larger doses may produce serious or even life threatening manifestations of toxicity. Levothyroxine replaces missing thyroxine and is the preferred medicine to treat hypothyroidism. Farwell AP, Braverman LE. Hypersensitivity to levothyroxine itself is not known to occur.Many drugs affect thyroid hormone pharmacokinetics and metabolism (e.g., synthesis, secretion, catabolism, protein binding, and target tissue response) and may alter the therapeutic response to Levothyroxine Sodium Injection (see Addition of levothyroxine to antidiabetic or insulin therapy may result in increased antidiabetic agent or insulin requirements. Hypothyroidism. Initiation of thyroid hormone therapy prior to initiating glucocorticoid therapy may precipitate an acute adrenal crisis in patients with adrenal insufficiency Addition of levothyroxine therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements. From FDA web site. From FDA website. Thyroid and antithyroid drugs. McEvoy GK, ed. Familial hyper- or hypo-thyroxine binding globulinemias have been described, with the incidence of TBG deficiency approximating 1 in 9,000.There is no available data with use of Levothyroxine Sodium Injection in pregnant women. )Manufacturer of IV levothyroxine states that relative bioavailability between oral and IV administration has been estimated to range from 48–74%.Currently approved levothyroxine preparations should be considered therapeutically Due to the long half-life, peak therapeutic effects may not be attained for 4–6 weeks.Infant soybean formula, soybean flour, cotton seed meal, walnuts, and foods containing large amounts of fiber may decrease absorption of levothyroxine.Thyroid hormones do not readily cross the placenta; however, some transfer does occur, as evidenced by levels in cord blood of athyrotic fetuses being approximately one-third maternal levels.Circulating thyroid hormones are >99% bound to plasma proteins, including TBG, thyroxine-binding prealbumin (TBPA), and albumin.Following reconstitution, the drug is stable for 4 hours; however, manufacturer states that reconstituted solutions should be used immediately.For information on systemic interactions resulting from concomitant use, see Interactions.Thyroid hormones also play an essential role in normal growth and development and normal maturation of the CNS and bone.The physiologic actions of thyroid hormones are produced predominantly by TImportance of understanding the need to continue levothyroxine therapy for life, unless transient hypothyroidism is suspected.Importance of taking levothyroxine exactly as prescribed;Importance of informing clinicians of existing or contemplated therapy, including prescription and OTC drugs and herbal supplements, as well as any concomitant illnesses (e.g., cardiovascular disease, diabetes mellitus, clotting disorders, adrenal or pituitary gland problems).In patients with diabetes mellitus, importance of monitoring blood and/or urinary glucose levels and immediately reporting any changes to a clinician.Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed.Importance of informing physician or dentist of current levothyroxine therapy prior to any surgery.Importance of informing patients of other important precautionary information. The liver is the major site of degradation for both T4 and T3, with T4 deiodination also occurring at a number of additional sites, including the kidney and other tissues. Furosemide has been shown to inhibit the protein binding of T4 to TBG and albumin, causing an increased free-T4 fraction in serum.

Bootman JL. Bioequivalence of levothyroxine preparations for treatment of hypothyroidism. 123. Biopharmaceutical comparison of two levothyroxine sodium products. Newborn screening for congenital hypothyroidism: recommended guidelines. (undated)139.

Manufacturer of IV levothyroxine states that myxedema coma is a disease of the elderly; an approved oral dosage form should be used in pediatric patients with noncomplicated hypothyroidism to maintain euthyroid state. Accessed October 2004. Bioequivalence of levothyroxine preparations for treatment of hypothyroidism. Bioequivalence of levothyroxine preparations: industry sponsorship and academic freedom. Williams textbook of endocrinology. Revision date: October 15, 2019.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

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