Abnormal heart rhythms: This medication can cause abnormal heart rhythms. Our guide will show you what puts you at risk, and how to take control of your heart health.Schwartz PJ, Woosley RL. (The QT interval may prolong during exercise in susceptible individuals.) For anyone else, these drugs apparently can be taken without worrying about the arrhythmias associated with a long-QT interval.

Certain medications (e.g., sotalol, quinidine, thioridazine, chlorpromazine, droperidol, pimozide, moxifloxacin, mefloquine, pentamidine, arsenic trioxide, probucol, tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with azithromycin. These drugs, in addition to antibiotics, include several antiarrhythmic medications (drugs that, ironically, are supposed to prevent arrhythmias), several antidepressant drugs, and several drugs used for gastrointestinal symptoms. In fact, similar to their azithromycin warning, the FDA released a warning in 2017 in regard to clarithromycin. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. In fact, similar to their azithromycin warning, the FDA released a warning in 2017 in regard to clarithromycin. Tachycardia, or a fast heart rate, can be caused by many medications, including antibiotics, antidepressants, and even certain supplements. Despite the particular publicity it has received, azithromycin does not appear to cause a greater degree of risk than any of the other drugs, on the long list of drugs, that can change the ECG in a similar way. If it’s happening because of a medicine you take, your doctor can make some changes that should help:Your doctor can also tell you which over-the-counter medicines are less likely to cause heart rhythm problems.FDA: “Learning About Side Effects,” “Thyroid Medications: Q & A with Mary Parks, M.D.”Mayo Clinic: “Tachycardia,” “Phenylephrine (Nasal Route),” “Albuterol Side Effects: Can I Avoid Them?”American Lung Association: “Asthma Medicines Chart.”Cleveland Clinic: “Your Heart and the Big 4 Med Types to Avoid,” “Heart Patients: 3 Common Medications You May Need to Avoid,” “Heart Palpitations.”American Academy of Family Physicians: “Decongestants: OTC Relief for Congestion,” “Types of Antidepressants.”Harvard Medical School: “Skipping a Beat—the Surprise of Heart Palpitations,” “Don’t Let Decongestants Squeeze Your Heart.”WebMD does not provide medical advice, diagnosis or treatment. Numerous genetic markers have been recognized that identify many of these susceptible people, and more such markers are being discovered all the time. Anyone who has one of these genetic markers should avoid azithromycin and any other drug on this list. Azithromycin belongs to the family of medications known as macrolide antibiotics. Common side effects of Zithromax include: diarrhea, loose stools, and nausea. That is, for people with a variant of the long QT syndrome or various kinds of heart disease, any of these drugs can be potentially dangerous. It is used to treat certain types of infections that are caused by bacteria. Cardiac arrhythmias that can produce sudden death have been reported with the other macrolide antibiotics. If you have a fast heart rate because of a medication, you also may feel:Whatever you think the reason may be, you should call 911 if you:Many of these can cause a fast heartbeat, including Talk to your doctor if you notice any changes in your heart rate.

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