Follow these directions carefully. The IOP-lowering of Cosopt administered twice a day was slightly less than that seen with the concomitant administration of 0.5% timol… Your doctor can discuss with you a more complete list of side effects. Dorzolamide: Sulfonamide and carbonic anhydrase inhibitor; inhibition of carbonic anhydrase in ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport

This is particularly important if you are taking medicine to lower blood pressure or to treat heart disease, medicines to treat diabetes, or if you are taking large doses of aspirin.Ask your doctor's advice about taking Cosopt if you are also using:Your doctor or pharmacist can tell you if any of the drugs you are using are in the above list.Any medicine may have unintended or undesirable effects. The most common side effects you may experience are:Other side effects may occur rarely, and some of these may be serious. In patients with impaired cardiac function, coadministration should be avoided.Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs, such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may result in vertigo, syncope, or postural hypotension.The concomitant use of beta-adrenergic blocking agents with digitalis and calcium antagonists may have additive effects in prolonging atrioventricular conduction time.Potentiated systemic beta-blockade (e.g., decreased heartrate, depression) has been reported during combined treatment with CYP2D6 inhibitors (e.g., quinidine, SSRIs) and timolol.Oral beta-adrenergic blocking agents may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. Used in the treatment of glaucoma.

A contaminated dropper can infect your eye, which could lead to serious vision problems.Do not use the eye drops if the liquid has changed colors or has particles in it.

Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Cosopt only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2020 Cerner Multum, Inc. Your list will be saved and can be edited at any time.The above information is provided for general

Patients suspected of developing thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of beta-adrenergic blocking agents that might precipitate a thyroid storm.Dorzolamide has not been studied in patients with severe renal impairment (CrCl <30 mL/min). Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.Use only the number of drops your doctor has prescribed.

No treatment-related tumors were seen in a 21-month study in female and male mice given oral doses up to 75 mg/kg/day (~900 times the recommended human ophthalmic dose).The increased incidence of urinary bladder papillomas seen in the high-dose male rats is a class-effect of carbonic anhydrase inhibitors in rats. Diseases & Conditions Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure: bradycardia, cardiac failure, cerebral vascular accident, chest pain, choroidal detachment following filtration surgery, depression, diarrhea, dry mouth, dyspnea, heart block, hypotension, iridocyclitis, myocardial infarction, nasal congestion, Stevens-Johnson syndrome, toxic epidermal necrolysis, paresthesia, photophobia, respiratory failure, skin rashes, urolithiasis, and vomiting.The following additional adverse reactions have been reported in clinical experience with ORAL timolol maleate or other ORAL beta-blocking agents and may be considered potential effects of ophthalmic timolol maleate: There is a potential for an additive effect on the known systemic effects of carbonic anhydrase inhibition in patients receiving an oral carbonic anhydrase inhibitor and Cosopt.

If you have high pressure in your eye, you will need your pressure checked and your eyes examined regularly.If you are not sure whether you should use Cosopt, contact your doctor or pharmacist.Cosopt is an eyedrop. You may need to stop using Cosopt for a short time.Store at room temperature away from moisture, heat, and light. Each of these two components decreases elevated …

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