& Laws, E. R. Jr. p53 expression in pituitary adenomas and carcinomas: correlation with invasiveness and tumor growth fractions.

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You are using a browser version with limited support for CSS. A. Angiogenesis in endocrine tumors. Thapar, K., Scheithauer, B. W., Kovacs, K., Pernicone, P. J. Close more info about Effects of Menopause on Prolactinoma Treatment Outcomes Post-Dopamine Agonist Withdrawal

Longer follow-up data are key, and the endocrine community awaits these data.Disclosure Summary: A.K. Author information: (1)Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark mia.jorgensen@studmed.au.dk.

Teixeira M, Souteiro P, Carvalho D. Prolactinoma management: predictors of remission and recurrence after dopamine agonists withdrawal. However, it is not certain whether menopause ensures tumor remission, as 7% of the total population experienced adenoma regrowth.Researchers cited certain limitations to their study, including potential selection bias related to the termination of dopamine agonist treatment.Despite these and other limitations, researchers said their results suggest that, “Despite the concept that menopause facilitates the remission of hyperprolactinemia in women with prolactinoma, progress of the tumor is possible, as seen in 2 of our 30 patients, necessitating regular monitoring.”Please login or register first to view this content.Copyright © 2020 Haymarket Media, Inc. All Rights ReservedYou’ve viewed {{metering-count}} of {{metering-total}} articles this month.

What is the duration of normoprolactinemia after withdrawal of therapy and what are the risks of tumor enlargement? Search for other works by this author on:

Close more info about Effects of Menopause on Prolactinoma Treatment Outcomes Post-Dopamine Agonist Withdrawal Anne Klibanski, Dopamine Agonist Therapy in Prolactinomas: When Can Treatment Be Discontinued?, The discovery and widespread use of dopamine agonists as an effective therapy for patients with prolactinomas was a key therapeutic advance.

A subset of patients who taper a dopamine agonist, however, develop dopamine agonist withdrawal syndrome (DAWS), which has been defined as a severe, stereotyped cluster of physical and psychological symptoms that correlate with dopamine agonist withdrawal in a dose-dependent manner, cause clinically significant distress or social/occupational dysfunction, are … Gillam, M. P., Molitch, M. E., Lombardi, G. & Colao, A. S. Savastano researched the data for the article and provided substantial contributions to discussions of the content.

The most important clinical problems associated with prolactinomas are hypogonadism, infertility and hyposexuality.

& Romijn, J. Andersohn, F. & Garbe, E. Cardiac and noncardiac fibrotic reactions caused by ergot-and nonergot-derived dopamine agonists.

George, L. D., Nicolau, N., Scanlon, M. F. & Davies, J. S. Recovery of growth hormone secretion following cabergoline treatment of macroprolactinomas. Prolactinomas are one of the most common pituitary adenomas and are diagnosed frequently in women of reproductive age. & Pivonello, R. Somatostatin analogues: treatment of pituitary and neuroendocrine tumors. Nevertheless, multimodal therapy that involves surgery, radiotherapy or both may be necessary in some cases, such as patients who are resistant to the effects of dopamine agonists or for those with atypical prolactinomas. Gu, H., Luck, S., Carroll, P. V., Powrie, J. Registration is free.Please login or register first to view this content. & Atkin, S. L. Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease. Novel data indicate that these agents can be successfully withdrawn in a subset of patients after normalization of prolactin levels and tumor disappearance, which suggests the possibility that medical therapy may not be required throughout life. To obtain

Delgrange, E., Daems, T., Verhelst, J., Abs, R. & Maiter, D. Characterization of resistance to the prolactin-lowering effects of cabergoline in macroprolactinomas: a study in 122 patients.

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