Because of the potential for TdP, use of dofetilide with maprotiline is contraindicated.Dofetilide therapy requires an experienced clinician trained in the management of serious ventricular arrhythmias.
Telithromycin is associated with QT prolongation and torsades de pointes TdP.Severe Coadministration of gemtuzumab ozogamicin with dofetilide is contraindicated due to the potential for additive QT interval prolongation and risk of torsade de pointes TdP. Moderate Colesevelam may decrease the absorption of oral antiarrhythmics. Intravenous Dofetilide Investigators. 1997;20(8):704-710. Severe Because of the potential for torsades de pointes TdPconcurrent use of dofetilide and chloroquine is contraindicated.Severe Because of the potential for torsade pcakage pointes TdPuse of panobinostat with dofetilide is contraindicated. Dofetilide does not increase the electrical energy required to convert electrically-induced ventricular fibrillation, and it significantly reduces the defibrillation threshold in patients with ventricular tachycardia and ventricular fibrillation undergoing implantation of a cardioverter-defibrillator device.Hawthorn thus has effects similar to the class III antiarrhythmics and would theoretically interact with drugs with similar cardiac pavkage e. Dofteilide Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required.QT prolongation and ventricular arrhythmias including fatal TdP have been reported with oxaliplatin use in post-marketing experience. These cookies will be stored in your browser only with your consent. Severe The concomitant use of erythromycin and dofetilide is contraindicated.The OBRA guidelines caution that antiarrhythmics can have serious adverse effects e. Dofetilide is a minor CYP3A4 substrate; however, because there is a linear relationship between dofetilide plasma concentration and QTc, concomitant administration of CYP3A4 inhibitors may increase the risk of arrhythmia torsade de pointes.If a breast-feeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA. Severe Limited data, including some case reports, suggest that quetiapine may be associated with a significant prolongation of the QTc interval in rare instances. QT prolongation has been reported with panobinostat therapy in patients with multiple myeloma in a clinical trial; use of panobinostat with other agents that prolong the QT interval is not recommended.Patients with atrial fibrillation AF should be anticoagulated according to usual medical practice prior to electrical or pharmacological cardioversion.Moderate Monitor for an increase in dofetilide-related adverse reactions, including QT prolongation, if coadministration inserf larotrectinib is necessary. The likelihood of QTc prolongation may increase with increasing dose of the drug; therefore, the recommended dose should not be exceeded especially in patients with renal or hepatic impairment where the Cmax and AUC are slightly higher.Severe Because of the potential for torsade de pointes TdPthe use of osimertinib with dofetilide is contraindicated.Bismuth Subcitrate Potassium; Metronidazole; Tetracycline: Related Drug Information Drug Summary.Patients receiving other drugs which dogetilide the potential for QT prolongation, such as class III antiarrhythmics, have an increased risk of developing proarrhythmias during bepridil therapy.In Decemberthe FDA issued a black box warning regarding the use of droperidol and its association with QT prolongation and potential for cardiac arrhythmias based on post-marketing surveillance data. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are as essential for the working of basic functionalities of the website.

Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: Because of the potential for TdP, use of dofetilide with fluconazole is contraindicated.Bictegravir; Emtricitabine; Tenofovir Alafenamide: Dofetilide is an antiarrhythmic drug with Vaughn Williams Class III cardiac action potential duration prolonging properties. But opting out of some of these cookies may have an effect on your browsing experience.Necessary cookies are absolutely essential for the website to function properly.

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