In patients with impaired renal function or undergoing chronic haemodialysis, a particularly low dosage of baclofen should be selected i.e. It is therefore recommended that a very cautious dosage schedule be adopted and that patients be kept under appropriate surveillance.Baclofen should be taken during meals with a little liquid.

Dilution: Baclofen oral liquid may be diluted with Purified Water and stored at room temperature for up to 28 days. In most cases, the patients had additional risk factors associated with an increased risk of suicide including alcohol use disorder, depression and/or a history of previous suicide attempts. An apparently dose related increase in the incidence of ovarian cysts, and a less marked increase in enlarged and/or haemorrhagic adrenals have been observed in female rats treated for 2 years. The following gradually increasing dosage regimen is suggested, but should be adjusted to suit individual patient requirements. dose escalation, drug-seeking behaviour, development of tolerance.Baclofen may also exacerbate epileptic manifestations but can be employed provided appropriate supervision and adequate anticonvulsive therapy are maintained. 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9.

A gamma-aminobutyric acid (GABA) derivative, chemically unrelated to other antispastic agents.Baclofen depresses monosynaptic and polysynaptic reflex transmission, probably by stimulating the GABAThe major benefits of baclofen stem from its ability to reduce painful flexor spasms and spontaneous clonus thereby facilitating the mobility of the patient, increasing their independence and helping rehabilitation.Baclofen also exerts an antinociceptive effect. Use in this patient population should be based on the physician's consideration of individual benefit and risk of therapy.Neonatal convulsions have been reported after intrauterine exposure to oral baclofen (see section 4.6). Patients suffering from these conditions should therefore be treated cautiously and kept under close surveillance.Suicide and suicide-related events have been reported in patients treated with baclofen. This information is intended for use by health professionalsExcipient with known effect: Each tablet contains 40 mg lactose monohydrateA 7 mm flat bevelled edge tablet marked “BN” breakline “10” on one side and “G” on the reverse.Baclofen is indicated for the relief of spasticity of voluntary muscle resulting from such disorders as multiple sclerosis, other spinal lesions e.g.

Baclofen is an antispastic agent acting at the spinal level. Neurological signs and symptoms of overdose including clinical manifestations of toxic encephalopathy (e.g. tumours of the spinal cord, syringomyelia, motor neurone disease, transverse myelitis, traumatic partial section of the cord.Baclofen is also indicated in adults and children for the relief of spasticity of voluntary muscle arising from e.g. Supportive measures and symptomatic treatment should be given for complications such as hypotension, hypertension, convulsions, gastrointestinal disorders and respiratory or cardiovascular depression. After ingestion of a potentially toxic amount, activated charcoal should be considered. The usual daily dosage for maintenance therapy ranges between 0.75 and 2mg/kg body weight. Supportive measures and symptomatic treatment should be given for complications such as hypotension, hypertension, convulsions, gastrointestinal disorders and respiratory or cardiovascular depression.Since the drug is excreted chiefly via the kidneys, generous quantities of fluid should be given, possibly together with a diuretic. Within 72 hours, about 75% of the dose is excreted via the kidneys with about 5% of this amount as metabolites. Composition comprising baclofen, or a salt, or derivative, or sustained release formulation thereof, for use in the treatment of alzheimer's disease Info Publication number IL208982A. Careful monitoring of respiratory and cardiovascular functions is essential especially in patients with cardiopulmonary disease and respiratory muscle weakness.

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