Take ondansetron exactly as directed. x��}M�-IR�>�]#��� �n$H�j�b�.�k�����c�n~�ۯ��GU5����"=�����-~�w������x��7����>��ͷo�f7�w����B{�?�j�������nx���o���x�A.�������߿�jL�m �~���o�����?o����Ͽ�w��Oo5�����
�~�_{q�>��:pw�����?����2QRuݗ9Q�����֟���������xWn-D3���t�.�����߷#a~X�x�����-���}˥�C�ל�cL�g�ꯞ��_J������|���j�ˎ���_��>��5���(�`)z�=�Y�K��c)�C�U�s���[�-��S0�{�Dr�p�7����r����Ɛz�7�F��_[����;�8���{�>�T1vs���B����El`~���'�{/9�^�k�ާd�������s|��{/�8��*�4��BID3��E㻏���V������c�x|w�!�tSo�6囚�B�z��p�d��_�^��=��8�ۻ1�O~��4�XJ.�)TW�A�z�o Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane.Panobinostat: Ondansetron may enhance the arrhythmogenic effect of Panobinostat. Instead, the best way to dispose of your medication is through a medicine take-back program. Management: Consider an alternative for one of the interacting drugs. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Call your doctor if you have any unusual problems while you are taking this medication.Keep this medication in the container it came in, tightly closed, and out of reach of children. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products.
Ondansetron treats and prevents nausea and vomiting by an unknown mechanism, possibly by a direct effect on the CTZ (the area of the brain associated with vomiting), the vagus nerve or both. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Subtract the weight of base displaced from the calculated weight of base required for each suppository. >> The first dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery. Ondansetron may mask progressive ileus and/or gastric distension; monitor for decreased bowel activity.ECG (if applicable in high-risk or elderly patients); potassium, magnesium. If combined, monitor for QTc interval prolongation and ventricular arrhythmias. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. stream 1) Ondansetron comes as a tablet, a rapidly disintegrating (dissolving) tablet, film, and an oral solution (liquid) to take by mouth. All rights reserved. The tablet will dissolve in a few seconds and can be swallowed with saliva.This medication may be prescribed for other uses. W�7c[���r������W����{�9%;�S�>���傃1_�M��$�X*V��)_A֪�9�N:��k����_�|�g�����:՚����X#�&�c�[3s_8)�[�dN
See the FDA's Safe Disposal of Medicines website (In case of overdose, call the poison control helpline at 1-800-222-1222. Pentamidine (Systemic): May enhance the QTc-prolonging effect of Ondansetron. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). 449.579999 0] Buy. Pour the mixture into the suppository mold and cool. %PDF-1.4 If commercial oral solution is unavailable, a 0.8 mg/mL syrup may be made with ondansetron tablets, Ora-Plus® (Paddock), and any of the the following syrups: Cherry syrup USP, Syrpalta® (HUMCO), Ora-Sweet® (Paddock), or Ora-Sweet® Sugar-Free (Paddock). If using more than one film, each film should be allowed to dissolve completely before administering the next film.Chemotherapy-induced nausea and vomiting: Give first dose 30 minutes prior to beginning chemotherapy.IV push: Prevention of postoperative nausea and vomiting: Single doses may be administered IV injection as undiluted solution over at least 30 seconds but preferably over 2 to 5 minutesOral soluble film: Store between 20°C and 25°C (68°F and 77°F). /Font << /Length 15 0 R Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Dose-dependent QT-interval prolongation can occur with use; therefore, ECG monitoring is recommended in patients with risk factors for arrhythmia (ACOG 2018); this may include patients with electrolyte abnormalities associated with some cases of NVP (Koren 2012).Ondansetron may be considered as part of a multimodal approach to prevent nausea and vomiting associated with cesarean delivery. /Parent 2 0 R >> Name /bks_53161_deglins_md_disk/ondansetron 02/17/2014 08:27AM Plate # 0-Composite pg 2 # 2 2015 F.A. It is also used to prevent nausea and vomiting that may occur after surgery. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Nausea and Vomiting Adult: PO 8 mg 30 min before chemotherapy, then q8h times 2 more doses Adult/ Child: IV 6 mo–18 y, 0.15 mg/kg or 32 mg infused over 15 min beginning 30 min before start of chemotherapy, followed by 0.15 mg/kg 4 and 8 h after first dose of ondansetron, may also give 8 mg bolus, then 1 mg/h by continuous infusion (max: 32 mg/d), or 32 mg as single dose If combined, monitor for QTc interval prolongation and ventricular arrhythmias.
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