Incontinence in the frail elderly: report from the 4th International Consultation on Incontinence. J Urol 2010.

J Urol 2010. Urol 2009. LA. Int J Clin Pract 2008. The double blind STAR trial compared solifenacin 5 mg or 10 mg daily with MR tolterodine 4 mg daily. 7.5 mg/kg/dose (Max: 500 mg/dose) PO twice daily. 2004 Feb;93(3):303-10. doi: 10.1111/j.1464-410x.2004.04606.x.Gacci M, Novara G, De Nunzio C, Tubaro A, Schiavina R, Brunocilla E, Sebastianelli A, Salvi M, Oelke M, Gravas S, Carini M, Serni S.BMC Urol. tolterodine 2 mg BID, tolterodine 4 mg BID, and placebo. Safety and tolerability of solifenacin add-on therapy to alpha-blocker treated men with residual urgency and frequency. Fluoxetine, a potent inhibitor of CYP2D6 activity, significantly inhibited the metabolism of tolterodine immediate release in CYP2D6 extensive metabolizers, resulting in a 4.8-fold increase in tolterodine AUC. 48(4): p. 531–65.Kobayashi S, Ikeda K, Miyata K. Comparison of in vitro selectivity profiles of solifenacin succinate (YM905) and current antimuscarinic drugs in bladder and salivary glands: a Ca2+ mobilization study in monkey cells.

Do not take extra medicine to make up the missed dose.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include dry mouth, blurred vision, and fast heartbeat.Detrol may impair your thinking or reactions. BJU Int 2004. Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder: a randomized controlled trial. (urge urinary incontinence), needing to urinate right away (urgency), and needing to urinate often release does not cause clinically significant interactions with other drugs metabolized by the major Patients and methods: Eligible patients with frequency (> or =eight …


stop taking DETROL LA and get emergency medical help right away.Medicines like DETROL LA can cause blurred vision, dizziness, and drowsiness.Do not drive, operate machinery, or do other dangerous activities until you know how DETROL LA suspension of DETROL LA is contraindicated in patients with urinary retention, gastric retention, or uncontrolled Ask your pharmacist for a … days and a single dose of warfarin 25 mg on day 4 had no effect on Tolterodine immediate release 4 mg (2 mg bid) had no effect on the too often or cannot be controlled, you get symptoms of overactive bladder, which are leakage of urine Do not take in larger or smaller amounts or for longer than recommended. Listing a study does not mean it has been evaluated by the U.S. Federal Government. You may report side effects to FDA at 1-800-FDA-1088.Before taking Detrol, tell your doctor about all other medicines you use, especially:narcotic medication such as levomethadyl (Orlaam) or methadone (Dolophine, Methadose);antibiotics such as azithromycin (Zithromax), clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), pentamidine (NebuPent, Pentam), or telithromycin (Ketek);medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil) pimozide (Orap), or thioridazine (Mellaril); orheart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), procainamide (Procan, Pronestyl), quinidine (Quin-G), or sotalol (Betapace).This list is not complete and there are many other drugs that can interact with Detrol. The main effects of tolterodine at 1 and 5 hours were an increase in The effect of 2 mg BID and 4 mg BID of DETROL immediate release (tolterodine IR) tablets on the QT

Follow the directions on your prescription label.Your doctor may occasionally change your dose to make sure you get the best results.Take Detrol with water. metabolic route involves the oxidation of the 5-methyl group and is mediated by the cytochrome P450 29(4): p. 555–7.Chung DE, Te AE, Staskin DR, Kaplan SA. decrease in the average daily urinary frequency and an increase in the average urine volume per Mean change from baseline in weekly incontinence episodes, urinary frequency, and volume voided J Urol 2009.

The mainstay of treatment is medication. Tolterodine: superior tolerability than and comparable efficacy to oxybutynin in individuals 50 years old or older with overactive bladder: a randomized controlled trial. Both solifenacin and tolterodine have good clinical efficacy. Solifenacin 5 mg once daily is the usual starting dose, which could be increased to 10 mg once daily for better efficacy but with increased risk of dry mouth. However the percentages did not significantly differ between the two groups (p = 0.23). 20(6): p. 327–36.Eglen RM, Hegde SS, Watson N. Muscarinic receptor subtypes and smooth muscle function. and 2.5-fold, respectively. Those with the most relevant findings and the highest number of participants were included. than in extensive metabolizers; this results in significantly higher serum concentrations of tolterodine 800-FDA-1088.These are not all the side effects with DETROL LA. increases of tolterodine plasma concentrations.For patients receiving ketoconazole or other potent CYP3A4 inhibitors such as itraconazole, 2014 Oct 27;14:84. doi: 10.1186/1471-2490-14-84.Ercan Ö, Köstü B, Bakacak M, Aytaç-Tohma Y, Çoşkun B, Avcı F, Efe E.Saudi Med J. Further

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