The possibility of interactions with other drugs administered concurrently should be considered, particularly when their main route of elimination is active renal secretion via the organic cationic transport system (e.g., trimethoprim) Coadministration of single doses of 3TC and sorbitol resulted in a sorbitol dose-dependent reduction in 3TC exposures. No clinically significant drug interactions have been observed between tenofovir and ribavirin.Achievement of plasma HIV-1 RNA concentrations of < 400 copies/mL at Week 144 was similar between the two treatment groups for the population stratified at baseline on the basis of HIV-1 RNA concentration (> or ≤ 100,000 copies/mL) and CD4+ cell count (< or ≥ 200 cells/mmThrough 144 weeks, 11 subjects in the TDF group and 9 subjects in the d4T group experienced a new CDC Class C event.The ENCORE1 trial was a randomized, multinational clinical study comparing EFV 400 mg vs. EFV 600 mg in 630 antiretroviral-naïve adult subjects. You may report side effects to the FDA at 1-800-332-1088. In general, caution should be exercised in the administration of 3TC in elderly patients reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.Efavirenz, Lamivudine and Tenofovir disoproxil fumarate is not recommended for patients with impaired renal function (i.e., creatinine clearance less than 50 mL/min) or patients with end-stage renal disease (ESRD) requiring hemodialysis because it is a fixed-dose combination formulation that cannot be adjusted Efavirenz, Lamivudine and Tenofovir disoproxil fumarate is not recommended for patients with moderate or severe hepatic impairment because there are insufficient data to determine whether dose adjustment is necessary. However, many people have no side effects or only have minor side effects. Patients with mild hepatic impairment may be treated with Efavirenz, Lamivudine and Tenofovir disoproxil fumarate without any adjustment in dose If overdose occurs, the patient must be monitored for evidence of toxicity, and standard supportive treatment applied as necessary.Efavirenz, Lamivudine and Tenofovir disoproxil fumarate is a fixed-dose combination tablet for oral administration. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skinwith or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mou… When psychiatric symptoms similar to those noted above were combined and evaluated as a group in a multifactorial analysis of data from a study using EFV 600 mg, treatment with EFV was associated with an increase in the occurrence of these selected psychiatric symptoms. Cholesterol and triglyceride testing should be performed before initiating EFV therapy and at periodic intervals during therapy.Immune reconstitution syndrome has been reported in HIV-infected patients treated with combination antiretroviral therapy, including EFV, 3TC, and TDF. Based on limited data at delivery, median (range) amniotic fluid concentrations of 3TC were 3.9 (1.2 to 12.8)-fold greater compared with paired maternal serum concentration (n = 8).Prospective reports from the APR of overall major birth defects in pregnancies exposed to TDF are compared with a U.S. background major birth defect rate. Examples include St. John's wort, some drugs used to treat Efavirenz/lamivudine/tenofovir can speed up the removal of other medications from your body, which may affect how they work. Properly discard this product when it is expired or no longer needed. Mild adverse reactions (Grade 1) were common with a similar incidence in both arms and included dizziness, diarrhea, and nausea. Doing so may cause the amount of virus to increase, make the infection more difficult to treat (resistant), or worsen side effects.If any of these effects last or get worse, tell your doctor or Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Call your doctor or get medical The study demonstrated that foetuses exposed The results of long-term carcinogenicity studies in rats and mice did not show any carcinogenic potential relevant for humans.A fertility study in rats has shown that lamivudine had no effect on male or female fertility.Non-clinical safety pharmacology studies reveal no special hazard for humans.

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