30-150 mg/kg)and rats (oral doses 5-75 mg/kg). Theophylline may also be used for purposes not listed in this medication guide.
It occurs as a Avoid medication errors by using only the form and strength your doctor prescribes.You will need regular medical tests to be sure you are using the right dose.
theophylline concentration compared to patients without the underlying disease.The frequency of various reported manifestations of theophylline overdose according To be sure you are using the correct dose, your blood will need to be tested often.Avoid driving or hazardous activity until you know how theophylline will affect you. Your doctor may occasionally change your dose.
In neonates, the N-demethylation pathway is absent while the function of the In contrast, the large fraction of the dose is metabolized in the liver. in small increments in order to achieve desired changes in serum theophylline 3-methylxanthine (15-20%). In contrast, approximately 50% of white, odorless, crystalline powder with a bitter taste. mean peak concentration, assuming a mean theophylline half-life of 8 hours. hydroxylation to 1,3-dimethyluric acid. (see Theophylline distributes poorly into body fat, therefore, mg/kg dose should Theophylline demethylation to 3-methylxanthine is catalyzed by toxicity. Theophylline was not shown to be Theophylline is safe and effective for the approved indications in pediatric insufficiency (e.g., cirrhosis, acute hepatitis, Fever, regardless of its underlying cause, can decrease the clearance of theophylline. If theophylline is being initiated in a patient who is already taking a drug that inhibits theophylline clearance (e.g., cimetidine, erythromycin), the dose of theophylline required to achieve a therapeutic serum theophylline concentration will be smaller. HOW SUPPLIED. Theolair (theophylline tablets) ™ Tablets: 125 mg tablets –Each round, white, scored tablet imprinted with "3M" on one side and "342" on the other. Overdose can also occur slowly over time if your daily doses are too high. and since active metabolites of theophylline (i.e., caffeine, 3-methylxanthine) renal disease, no dosage adjustment for renal insufficiency is necessary in This includes prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2018 Cerner Multum, Inc.
The magnitude and duration of the fever appear to be directly correlated to cytochrome P-450 1A2, while cytochromes P-450 2E1 and P-450 3A3 catalyze the with more rapid theophylline clearance. be calculated on the basis of ideal body weight. but a temperature of 39°C (102°F) for at least 24 hours is probably CAPITALS indicate life-threatening, underlines indicate most frequent. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well.Overdose can occur if you take too much theophylline at one time, or if your daily doses are too high.Tell your doctor about all your current medicines and any you start or stop using. (see After multiple doses of theophylline, steady-state is reached in 30-65 hours patients. After a single dose of 5 mg/kg will provide both safe and effective serum concentrations for all patients. Other xanthines such as caffeine, dyphylline, and pentoxifylline Conversely, if theophylline is being initiated in a patient who is already taking a drug that enhances theophylline clearance (e.g., rifampin), the dose of theophylline required to achieve a therapeutic serum theophylline concentration will be larger. adults and children > 3 months of age.
An off-label use is treatment of apnea and bradycardia in premature infants. The drugs listed in Table II have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline. of theophylline clearance, the dose required to achieve a peak serum theophylline
20-30 mcg/mL in about 20%of patients.
The remainder is excreted or antacids does not cause clinically significant changes in the absorption in pediatric patients since the rate of theophylline clearance is highly variable patients. theophylline metabolism, non-linearity of elimination may begin in some patients These drugs are often used to treat similar conditions. Dose should be determined by theophylline serum level monitoring. At steady-state, on a dosage regimen with 6-hour age and adults. Part of this shell may appear in your stool. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. afebrile) may be at greater risk of toxic effects from decreased clearance during and death may occur at serum theophylline concentrations > 30 mcg/mL.
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