Fluoxetine by Meliapharm Inc.: Fluoxetine belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). Tachycardia and an increase in blood pressure were observed. In many cases, this hyponatremia appears to be the result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Anxiety was reported in 14% of patients treated with Fluoxetine and in 7% of patients treated with placebo.In U.S. placebo-controlled clinical trials for Bulimia Nervosa, insomnia was reported in 33% of patients treated with Fluoxetine 60 mg, and 13% of patients treated with placebo. Consequently, the value of the ECG in predicting cardiac toxicity is unknown. Fluoxetine (60 mg single dose or 60 mg daily dose for 8 days) causes a small (mean 16%) increase in the maximum concentration of olanzapine and a small (mean 16%) decrease in olanzapine clearance. Fluoxetine is primarily metabolized by CYP2D6. Signs and symptoms of ventricular arrhythmia include fast, slow, or irregular heart rate, dyspnea, syncope, or dizziness, which may indicate serious cardiac arrhythmia Fluoxetine may impair judgment, thinking, or motor skills. Women who discontinued antidepressant medication during pregnancy showed a significant increase in relapse of their major depression compared to those women who remained on antidepressant medication throughout pregnancy.When treating a pregnant woman with Fluoxetine, the physician should carefully consider both the potential risks of taking an SSRI, along with the established benefits of treating depression with an antidepressant. Rat exposures to the major metabolite, norFluoxetine, were approximately 0.3 to 0.8, 1 to 8, and 3 to 20 times, respectively, the pediatric exposure at the MRHD.A specific effect on bone development was reported in juvenile mice administered Fluoxetine by the intraperitoneal route to 4-week-old mice for 4 weeks at doses 0.5 and 2 times the oral MRHD of 20 mg/day on a mg/mU.S.

All rights reserved. Several recent epidemiological studies suggest a positive statistical association between SSRI use (including Fluoxetine) in pregnancy and PPHN. The magnitude of the impact of this factor is small in comparison to the … Prozac. Fluoxetine tablets can also prolong the QT interval.Patients with MDD, both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs. The percentage appears to be similar to that associated with other marketed drugs effective in the treatment of MDD. PPHN occurs in 1 to 2 per 1000 live births in the general population and is associated with substantial neonatal morbidity and mortality. Such monitoring should include daily observation by families and caregivers. Patients in these 3 studies had moderate to severe bulimia with median binge-eating and vomiting frequencies ranging from 7 to 10 per week and 5 to 9 per week, respectively. Panic Disorder. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. The efficacy in geriatric patients has been established In subjects with cirrhosis of the liver, the clearances of Fluoxetine and its active metabolite, norFluoxetine, were decreased, thus increasing the elimination half-lives of these substances. Patients in the 8-week studies received either 20 or 60 mg/day of Fluoxetine or placebo in the morning. It is very important that you read and understand this information. Caution is advisable in using Fluoxetine in patients with diseases or conditions that could affect metabolism or hemodynamic responses.As with any CNS-active drug, Fluoxetine has the potential to impair judgment, thinking, or motor skills.

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