You may report side effects to FDA at 1-800-FDA-1088.Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. It is not for oral, ophthalmic, or intravaginal use.Avoid contact with eyes. Three of the 8 normal subjects on whom clotrimazole and betamethasone dipropionate cream was applied exhibited low morning plasma cortisol levels during treatment. However, greater sensitivity of some older individuals cannot be ruled out. However, clotrimazole dosed at 100 mg/kg/day was embryotoxic (increased resorptions), fetotoxic (reduced fetal weights), and maternally toxic (reduced body weight gain) to rats. Epidermophyton floccosum, Trichophyton mentagrophytes,Epidermophyton floccosum, Trichophyton mentagrophytes,Betamethasone Dipropionate (bay" ta meth' a sone dye proe' pee oh nate)Clotrimazole and betamethasone dipropionate cream is for use on skin only.clotrimazole and betamethasone dipropionate cream, tell your healthcare provider about all your medical conditions, including if you:Tell your healthcare provider about all the medicines you take,For treatment of fungal infections of the groin and body:Clotrimazole and betamethasone dipropionate cream may cause serious side effects, including:Clotrimazole and betamethasone dipropionate cream can pass through your skin.clotrimazole and betamethasone dipropionate cream includeGeneral information about the safe and effective use ofClotrimazole and Betamethasone Dipropionate Cream USP, 1%/0.05% (base)FOR TOPICAL USE ONLY. NOT FOR OPTHALMIC, ORAL, OR INTRAVAGINAL USE.We comply with the HONcode standard for trustworthy health information - However, similar blanching scores do not necessarily imply therapeutic equivalence.Skin penetration and systemic absorption of clotrimazole and betamethasone dipropionate following topical application of clotrimazole and betamethasone dipropionate cream has not been studied.The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. No evidence of maternal toxicity or embryotoxicity was seen in pregnant rabbits dosed orally during organogenesis with 60, 120, or 180 mg/kg/day.Betamethasone dipropionate caused malformations when given to pregnant rabbits during organogenesis by the intramuscular route at doses of 0.05 mg/kg/day. Inflammation and/or other disease processes in the skin may increase percutaneous absorption of topical corticosteroids. Factors that predispose a patient to HPA axis suppression include the use of high-potency steroids, large treatment surface areas, prolonged use, use of occlusive dressing, altered skin barrier, liver failure, and young age.Because of the potential for systemic corticosteroid effects, patients may need to be periodically evaluated for HPA axis suppression. Cataracts and glaucoma have been reported in postmarketing experience with the use of topical corticosteroid products, including topical betamethasone products Avoid contact of clotrimazole and betamethasone dipropionate cream with eyes. Cushing’s syndrome and hyperglycemia may also occur due to the systemic effect of corticosteroids while on treatment. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. This may be done by using the adrenocorticotropic hormone (ACTH) stimulation test.In a small trial, clotrimazole and betamethasone dipropionate cream was applied using large dosages, 7 g daily for 14 days (BID) to the crural area of normal adult subjects.

The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for clotrimazole and betamethasone dipropionate cream and any potential adverse effects on the breastfed infant from clotrimazole and betamethasone dipropionate cream or from the underlying maternal condition.To minimize potential exposure to the breastfed infant via breast milk, use clotrimazole and betamethasone dipropionate cream on the smallest area of skin and for the shortest duration possible while breastfeeding. No adverse effects on the duration of estrous cycle, fertility, or duration of pregnancy were noted.In clinical trials of tinea corporis, tinea cruris, and tinea pedis, subjects treated with clotrimazole and betamethasone dipropionate cream showed a better clinical response at the first return visit than subjects treated with clotrimazole cream. The use of clotrimazole and betamethasone dipropionate cream under occlusion, such as in diaper dermatitis, is not recommended.Postmarket adverse event reporting for clotrimazole and betamethasone dipropionate cream in patients aged 65 and above includes reports of skin atrophy and rare reports of skin ulceration.

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