Gallant JE, DeJesus E, Arribas JR et al. 43. Determination of the pK6. Centers for Disease Control and Prevention. 2006;4(3) © 2006 Massachusetts Medical Society Click the topic below to receive emails when new articles are available. If you log out, you will be required to enter your username and password the next time you visit. 76.
367. http://www.aidsinfo.nih.gov202. Young SD, Britcher SF, Tran LE et al. Izzedine H, Aymard G, Launay-Vacher V et al. Swallow efavirenz tablets and capsules whole with liquid. Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Tashima KT, Caliendo AM, Ahmad M et al. Although similar considerations have been emphasized in the use of nevirapine to prevent maternal-fetal transmission (AIDS Clinical Care. Introduction. Effects of valproic acid coadministration on plasma efavirenz and lopinavir concentrations in human immunodeficiency virus-infected adults. We comply with the HONcode standard for trustworthy health information - 77. Centers for Disease Control and Prevention. Presented at 36th annual meeting of Infectious Disease Society of America, Denver, CO: 1998 Nov 12-15. Merluzzi VJ, Hargrave KD, Labadia M et al. This report is the first to examine the role of efavirenz-elimination pharmacokinetics and pharmacogenetics in the emergence of resistance after discontinuation of … Bacheler L, Jeffrey S, Hanna G et al. 461.57. 65. 41. 22. A phase II, double-blind, placebo-control, dose-ranging study to assess the antiretroviral activity & safety of efavirenz (EFV, sustiva, DMP266) in combination with open-label zidovudine (ZDV) w/ lamivudine (3TC) at >48 weeks [DMP266-005]. 13–15 The 8-OH-efavirenz metabolite was found to induce direct neuronal toxicity and death via increased Ca 2+ influx in vitro. Available for Android and iOS devices. Selection conditions affect the evolution of specific mutations in the reverse transcriptase gene associated with resistance to DMP 266. Daily efavirenz 400 mg (EFV400) was virologically noninferior to 600 mg (EFV600) at 48 weeks in treatment‐naïve patients. Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV. 68. Updated guidelines for antiretroviral postexposure prophylaxis after sexual, injection drug use, or other nonoccupational exposure to HIV – United States, 2016. 23. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication.
Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States (October 26, 2016).
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. 13–16 Additionally, there is a subsequent pathway via CYP2A6 to a 7-OH-efavirenz metabolite. 4. Antiretroviral drug resistance testing in adults with HIV infection. 2001http://www.medscape.com/mtv/hiv-s03/e02 AbbVie, Inc. Viekira XR (dasabuvir, ombitasvir, paritaprevir, and ritonavir) extended-release tablets prescribing information. Centers for Disease Control and Prevention. Pharmacokinetics of efavirenz in a patient on maintenance haemodialysis. Maserati R, Villani P, Seminari E et al.
http://www.aidsinfo.nih.gov232. Please confirm that you would like to log out of Medscape. We evaluated EFV400 and EFV600 pharmacokinetics (NONMEM v. 7.2), assessing patient demographics and genetic polymorphisms (CYP2B6, CYP2A6, CYP3A4, NR1I3) as covariates and explored relationships with efficacy (plasma HIV‐RNA (pVL) <200 … Pharmacokinetics of efavirenz (EFV) and ritonavir (RIT) after multiple oral doses in healthy volunteers. 59.
From web site.
Pharmacokinetic interaction of digoxin with an herbal extract from St.John’s wort (66. Vandamme AM, Van Laethem K, De Clercq E. Managing resistance to anti-HIV drugs: an important consideration for effective disease management.
Panel on Antiretroviral Therapy and Medical Management of HIV-infected Children, US Department of Health and Human Services (HHS). Please see our Comments on Medscape are moderated and should be professional in tone and on topic. 61. 32. Bristol-Myers Squibb and Gilead Sciences.
17. In a pharmacogenetics substudy of ACTG 5095, researchers examined 152 patients who were antiretroviral-naive before receiving two NRTIs plus efavirenz. 15.
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