Drug Aliases Actions ; Abacavir: Ziagen, Trizivir, Kivexa Please Click here to learn more about the WPS genes that have CPIC guidelines. It is increased by a factor of 1.5 to 3.0 when the creatinine clearance is less than 10 ml/minute. If the patient misses a dose of Descovy within 18 hours of the time it is usually taken, the patient should take Descovy as soon as possible and resume the normal dosing schedule.

Adult doses of 6 to 8 tablets daily for up to 3 months have been used.There is no consensus on the most appropriate dosage for the treatment or prophylaxis of this condition. Supplementation with folinic acid may be considered during treatment but this should be initiated with caution due to possible interference with antimicrobial efficacy (see section 4.5).In glucose-6-phosphate dehydrogenase (G-6-PD) deficient patients haemolysis may occur.Co-trimoxazole should be given with caution to patients with severe allergy or bronchial asthma.Co-trimoxazole should not be used in the treatment of streptococcal pharyngitis due to Group A beta-haemolytic Trimethoprim has been noted to impair phenylalanine metabolism but this is of no significance in phenylketonuric patients on appropriate dietary restriction.The administration of co-trimoxazole to patients known or suspected to be at risk of acute porphyria should be avoided. Trimethoprim passes into amniotic fluid and foetal tissues reaching concentrations approximating those of maternal serum.In elderly patients there is a reduced renal clearance of sulfamethoxazole.The elimination half-life of trimethoprim is increased by a factor of 1.5-3.0 when the creatinine clearance is less than 10 mL/minute. Its affinity for mammalian DHFR is some 50,000 times less than for the corresponding bacterial enzyme.S = susceptible, R = resistant. Dosages Parenteral Nutrition General Information Antimicrobial Guidelines. Posology. In addition, adverse events may vary in their incidence depending on the indication.Data from large published clinical trials were used to determine the frequency of very common to rare adverse events.

Most of the changes cause no clinical symptoms although they may become severe in isolated cases, especially in the elderly, in those with hepatic or renal dysfunction or in those with poor folate status.

Trimethoprim reversibly inhibits bacterial dihydrofolate reductase (DHFR), an enzyme active in the folate metabolic pathway converting dihydrofolate to tetrahydrofolate.Depending on the conditions the effect may be bactericidal.

Levels in the aqueous humor, breast milk, cerebrospinal fluid, middle ear fluid, synovial fluid and tissue (intestinal) fluid are adequate for antibacterial activity. By continuing to browse the site you are agreeing to our policy on the use of cookies. Early withdrawal is associated with a better prognosis.- If the patient has developed SJS or TEN with the use of co-trimoxazole, co-trimoxazole must not be re-started in this patient at any time.For patients with known renal impairment special measures should be adopted (see section 4.2).An adequate urinary output should be maintained at all times. Sign out. If clinical improvement is not evident after 7 days therapy, the patient should be reassessed.As an alternative to Standard Dosage for acute uncomplicated lower urinary tract infections, short-term therapy of 1 to 3 days duration has been shown to be effective.See Special Warnings and Precautions for Use (Section 4.4). *The WPS gene-drug database is created based on the Clinical Pharmacogenomics Implementation Consortium (CPIC) According to CPIC, “only CPIC level A and B gene/drug pairs have sufficient evidence for at least one prescribing action to be recommended. It allows continued monitoring of the benefit/risk balance of the medicinal product.

Neither component has an appreciable effect on the concentrations achieved in the blood by the other.Approximately 50% of trimethoprim in the plasma is protein bound.
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Drug Aliases Actions ; Abacavir: Ziagen, Trizivir, Kivexa Please Click here to learn more about the WPS genes that have CPIC guidelines. It is increased by a factor of 1.5 to 3.0 when the creatinine clearance is less than 10 ml/minute. If the patient misses a dose of Descovy within 18 hours of the time it is usually taken, the patient should take Descovy as soon as possible and resume the normal dosing schedule.

Adult doses of 6 to 8 tablets daily for up to 3 months have been used.There is no consensus on the most appropriate dosage for the treatment or prophylaxis of this condition. Supplementation with folinic acid may be considered during treatment but this should be initiated with caution due to possible interference with antimicrobial efficacy (see section 4.5).In glucose-6-phosphate dehydrogenase (G-6-PD) deficient patients haemolysis may occur.Co-trimoxazole should be given with caution to patients with severe allergy or bronchial asthma.Co-trimoxazole should not be used in the treatment of streptococcal pharyngitis due to Group A beta-haemolytic Trimethoprim has been noted to impair phenylalanine metabolism but this is of no significance in phenylketonuric patients on appropriate dietary restriction.The administration of co-trimoxazole to patients known or suspected to be at risk of acute porphyria should be avoided. Trimethoprim passes into amniotic fluid and foetal tissues reaching concentrations approximating those of maternal serum.In elderly patients there is a reduced renal clearance of sulfamethoxazole.The elimination half-life of trimethoprim is increased by a factor of 1.5-3.0 when the creatinine clearance is less than 10 mL/minute. Its affinity for mammalian DHFR is some 50,000 times less than for the corresponding bacterial enzyme.S = susceptible, R = resistant. Dosages Parenteral Nutrition General Information Antimicrobial Guidelines. Posology. In addition, adverse events may vary in their incidence depending on the indication.Data from large published clinical trials were used to determine the frequency of very common to rare adverse events.

Most of the changes cause no clinical symptoms although they may become severe in isolated cases, especially in the elderly, in those with hepatic or renal dysfunction or in those with poor folate status.

Trimethoprim reversibly inhibits bacterial dihydrofolate reductase (DHFR), an enzyme active in the folate metabolic pathway converting dihydrofolate to tetrahydrofolate.Depending on the conditions the effect may be bactericidal.

Levels in the aqueous humor, breast milk, cerebrospinal fluid, middle ear fluid, synovial fluid and tissue (intestinal) fluid are adequate for antibacterial activity. By continuing to browse the site you are agreeing to our policy on the use of cookies. Early withdrawal is associated with a better prognosis.- If the patient has developed SJS or TEN with the use of co-trimoxazole, co-trimoxazole must not be re-started in this patient at any time.For patients with known renal impairment special measures should be adopted (see section 4.2).An adequate urinary output should be maintained at all times. Sign out. If clinical improvement is not evident after 7 days therapy, the patient should be reassessed.As an alternative to Standard Dosage for acute uncomplicated lower urinary tract infections, short-term therapy of 1 to 3 days duration has been shown to be effective.See Special Warnings and Precautions for Use (Section 4.4). *The WPS gene-drug database is created based on the Clinical Pharmacogenomics Implementation Consortium (CPIC) According to CPIC, “only CPIC level A and B gene/drug pairs have sufficient evidence for at least one prescribing action to be recommended. It allows continued monitoring of the benefit/risk balance of the medicinal product.

Neither component has an appreciable effect on the concentrations achieved in the blood by the other.Approximately 50% of trimethoprim in the plasma is protein bound.

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