Subclinical and overt thyroid dysfunction and risk of all-cause mortality and cardiovascular events: a large population study. It’s important, however, to get Too little iodine can lead to hypothyroidism. Ryff AS, Subclinical hyperthyroidism is associated with an increased risk of atrial fibrillation and heart failure in older adults, increased cardiovascular and all-cause mortality, and decreased bone mineral density and increased bone fracture risk in postmenopausal women. Tunbridge WM, Trabucco P, A possible association between subclinical hyperthyroidism and quality-of-life parameters and cognition is controversial. Patsch W. Copyright © 1998 by the American Academy of Family Physicians.Copyright © 2020 American Academy of Family Physicians. Bacharach P, Thyroid hormones help control body temperature, heart rate, growth, and weight. Antithyroid drugs and radioactive iodine are appropriate treatment options in patients with Graves disease.This article updates previous articles on this topic by 29. Haemodynamic changes following treatment of subclinical and overt hyperthyroidism. et al. et al. Greater magnitude and duration of TSH elevation and higher titers of antithyroid antibodies increase the probability that the condition will progress to overt hypothyroidism and, therefore, increase the potential benefit of treatment with levothyroxine. Verga S, Although the condition may resolve or remain unchanged, within a few years in some patients, overt hypothyroidism develops, with low free T4 levels as … Staub JJ, et al. The Colorado thyroid disease prevalence study. Some studies,In several studies, a sensitive measure of myocardial contractility, the ratio of pre-ejection period to left ventricular ejection time (PEP:LVET) was shown to improve significantly in patients with subclinical hypothyroidism who were treated with levothyroxine, compared with patients who were treated with placebo.Indications for treatment in subclinical hypothyroidism are not established, but general guidelines can be offered. et al. Burch HB, The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. Access This ArticleINES DONANGELO, MD, PhD, is a staff endocrinologist at Allegheny Health Network, Pittsburgh, Pa., and an assistant professor of medicine at Drexel University College of Medicine, Philadelphia, Pa.SE YOUNG SUH, MD, is an endocrinology fellow at Allegheny Health Network Medical Education Consortium, Pittsburgh.Author disclosure: No relevant financial affiliations. Daniels GH. The prevalence of subclinical hyperthyroidism in the general population is about 1% to 2%; however, it may be higher in iodine-deficient areas. Topliss DJ, et al. A double-blind cross-over 12-month study of L-thyroxine treatment of women with ‘subclinical’ hypothyroidism. et al. When symptoms do arise, however, they tend to be vague and general and include:It’s important to note that these symptoms are nonspecific, meaning they can be present in individuals with normal thyroid function and not related to subclinical hypothyroidism.A person with a normal functioning thyroid should have a blood TSH reading within the normal reference range, which commonly goes up to However, there’s debate underway in the medical community about lowering the highest normal threshold.People with a TSH level above the normal range, who have normal thyroid gland hormone levels, are considered to have subclinical hypothyroidism.

2019 Mar 20;12:369-376. doi: 10.2147/DMSO.S181470. Epub 2019 Sep 1.Diabetes Metab Syndr Obes. Thyroxine replacement therapy and circulating lipid concentrations. Takamatsu J, Spectrum of subclinical and overt hypothyroidism: effect on thyrotropin, prolactin, and thyroid reserve, and metabolic impact on peripheral target tissues. Nanchen D, In patients with subclinical hypothyroidism, not surprisingly, the same changes are present but are less marked and less consistent. Nony P, Gaitonde DY. Abraham-Nordling M, Clinical review: The thyroid in mind: cognitive function and low thyrotropin in older people.

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